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p4ha2 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2 [ Danio rerio (zebrafish) ]

Gene ID: 373132, updated on 18-Sep-2024

Summary

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Official Symbol
p4ha2provided by ZNC
Official Full Name
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030827-1
See related
Ensembl:ENSDARG00000010085 AllianceGenome:ZFIN:ZDB-GENE-030827-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:91948
Summary
Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be involved in peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including axis; heart rudiment; margin; notochord; and tail bud. Human ortholog(s) of this gene implicated in myopia. Orthologous to human P4HA2 (prolyl 4-hydroxylase subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See p4ha2 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (43097860..43131752, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (43102684..43136893, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene janus kinase and microtubule interacting protein 2 Neighboring gene prolyl 4-hydroxylase subunit alpha-2 Neighboring gene heat shock protein 4a Neighboring gene zinc finger, CCHC domain containing 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function. Hyvärinen J, et al. J Biol Chem, 2010 Dec 31. PMID 20952382, Free PMC Article
  2. An expression pattern screen for genes involved in the induction of the posterior nervous system of zebrafish. Yoda H, et al. Differentiation, 2003 Mar. PMID 12641569
  3. Common responses of fish embryos to metals: an integrated analysis of transcriptomes and methylomes in zebrafish embryos under the stress of copper ions or silver nanoparticles. Tai Z, et al. Metallomics, 2019 Sep 1. PMID 31468037
  4. Coherent but overlapping expression of microRNAs and their targets during vertebrate development. Shkumatava A, et al. Genes Dev, 2009 Feb 15. PMID 19240133, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. transmembrane prolyl 4-hydroxylase in the zebrafish has a role in basement membrane and kidney function
    Title: Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables procollagen-proline 4-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables procollagen-proline 4-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
prolyl 4-hydroxylase subunit alpha-2
Names
prolyl 4-hydroxylase A
NP_001007286.1
XP_005173949.1
XP_005173950.1
XP_005173951.1
XP_009293964.1
XP_068071911.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007285.1 → NP_001007286.1  prolyl 4-hydroxylase subunit alpha-2 precursor

    See identical proteins and their annotated locations for NP_001007286.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076508
    UniProtKB/TrEMBL
    A0A0R4IKZ3, A0A8N7XJK4, B2GRW7, Q6DG45
    Related
    ENSDARP00000027028.6, ENSDART00000024137.8
    Conserved Domains (2) summary
    smart00702
    Location:347 → 498
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:25 → 154
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    43097860..43131752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173893.5 → XP_005173950.1  prolyl 4-hydroxylase subunit alpha-2 isoform X3

    UniProtKB/TrEMBL
    A0A286Y8C8, A0A8M2BLK0
    Related
    ENSDARP00000143396.1, ENSDART00000174463.2
    Conserved Domains (2) summary
    smart00702
    Location:347 → 520
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:25 → 154
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

  2. XM_005173894.5 → XP_005173951.1  prolyl 4-hydroxylase subunit alpha-2 isoform X4

    UniProtKB/TrEMBL
    A0A8M2BL71
    Conserved Domains (2) summary
    smart00702
    Location:347 → 518
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:25 → 154
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

  3. XM_005173892.5 → XP_005173949.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BL82
    Conserved Domains (2) summary
    smart00702
    Location:353 → 526
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:25 → 154
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

  4. XM_009295689.4 → XP_009293964.1  prolyl 4-hydroxylase subunit alpha-2 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AX68
    Conserved Domains (2) summary
    smart00702
    Location:353 → 524
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:25 → 154
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

  5. XM_068215810.1 → XP_068071911.1  prolyl 4-hydroxylase subunit alpha-2 isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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