hs6st2 heparan sulfate 6-O-sulfotransferase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hs6st2provided by ZNC
Official Full Name: heparan sulfate 6-O-sulfotransferase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030909-14
See related: Ensembl:ENSDARG00000012025 AllianceGenome:ZFIN:ZDB-GENE-030909-14
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hs6st; fb80f12; wu:fb80f12
Summary: Enables heparan sulfate 6-O-sulfotransferase activity. Acts upstream of or within branching involved in blood vessel morphogenesis and embryonic eye morphogenesis. Predicted to be located in membrane. Is expressed in several structures, including immature eye; nervous system; neural keel; somite; and tail bud. Human ortholog(s) of this gene implicated in Paganini-Miozzo syndrome. Orthologous to human HS6ST2 (heparan sulfate 6-O-sulfotransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (31081862..31087830, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (30741548..30747485, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

hs6st2 is required for the branching morphogenesis of the caudal vein during embryonic development.
Title: A unique role for 6-O sulfation modification in zebrafish vascular development.

Submit: New GeneRIF Correction

General gene information

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Markers

fb80f12.x1 (e-PCR)
- UniSTS:191577

fb80f12.x1 (e-PCR)
- UniSTS:191578

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heparan sulfate 6-O-sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables heparan sulfate 6-O-sulfotransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within muscle organ development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heparan-sulfate 6-O-sulfotransferase 2

Names: HS 6-OST-2; HS6ST-2

NP_919402.2

EC 2.8.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.