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siah2l seven in absentia homolog 2 (Drosophila)-like [ Danio rerio (zebrafish) ]

Gene ID: 378728, updated on 2-Nov-2024

Summary

Official Symbol
siah2lprovided by ZNC
Official Full Name
seven in absentia homolog 2 (Drosophila)-likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030922-1
See related
Ensembl:ENSDARG00000044381 AllianceGenome:ZFIN:ZDB-GENE-030922-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
siaz; zgc:66284
Summary
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of circadian rhythm. Predicted to act upstream of or within rhythmic process. Predicted to be active in cytoplasm. Is expressed in several structures, including dorsal aorta; male organism; nervous system; optic fissure; and otic vesicle. Orthologous to human SIAH2 (siah E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See siah2l in Genome Data Viewer
Location:
chromosome: 21
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (38657966..38717856, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (38610260..38670150, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 119 Neighboring gene RNA binding motif protein X-linked 2 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor Neighboring gene RAB24, member RAS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within mitotic cell cycle checkpoint signaling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase Siah2
Names
RING-type E3 ubiquitin transferase SIAH2
seven in absentia 2-like
seven in absentia homolog 2-like
siah-2
ubiquitin ligase siah2
NP_956721.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200427.2NP_956721.2  E3 ubiquitin-protein ligase Siah2

    Status: VALIDATED

    Source sequence(s)
    AL935199, CF996038, CU694657, DT068839
    UniProtKB/TrEMBL
    A0A8N1TYI4, G8JL17
    Related
    ENSDARP00000065168.4, ENSDART00000065169.6
    Conserved Domains (1) summary
    pfam03145
    Location:130326
    Sina; Seven in absentia protein family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    38657966..38717856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395097.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    466012..468552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)