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atp2b1a ATPase plasma membrane Ca2+ transporting 1a [ Danio rerio (zebrafish) ]

Gene ID: 378746, updated on 18-Sep-2024

Summary

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Official Symbol
atp2b1aprovided by ZNC
Official Full Name
ATPase plasma membrane Ca2+ transporting 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030925-29
See related
Ensembl:ENSDARG00000012684 AllianceGenome:ZFIN:ZDB-GENE-030925-29
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pmca1; pmca1a; sb:cb801; wu:fe47b06; wu:fi41d01; si:dkey-18o7.1
Summary
Predicted to enable P-type calcium transporter activity and PDZ domain binding activity. Acts upstream of or within animal organ development and sensory perception of sound. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in intracellular membrane-bounded organelle. Predicted to be integral component of plasma membrane. Is expressed in several structures, including digestive system; hematopoietic system; midbrain neural tube; nervous system; and pleuroperitoneal region. Orthologous to human ATP2B1 (ATPase plasma membrane Ca2+ transporting 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See atp2b1a in Genome Data Viewer
Location:
chromosome: 4
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (16076719..16124431, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (16077964..16125664, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103910441 Neighboring gene uncharacterized LOC100535588 Neighboring gene uncharacterized LOC101885185 Neighboring gene uncharacterized LOC137491536 Neighboring gene uncharacterized LOC103910439 Neighboring gene si:dkeyp-38g8.5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Plasma membrane calcium ATPase required for semicircular canal formation and otolith growth in the zebrafish inner ear. Cruz S, et al. J Exp Biol, 2009 Mar. PMID 19218514
  2. atp2b1a regulates Ca(2+) export during differentiation and regeneration of mechanosensory hair cells in zebrafish. Go W, et al. Cell Calcium, 2010 Nov. PMID 21084119
  3. Mitochondrial Calcium Uniporter Deficiency in Zebrafish Causes Cardiomyopathy With Arrhythmia. Langenbacher AD, et al. Front Physiol, 2020. PMID 33424641, Free PMC Article
  4. Plasma membrane Ca(2+) ATPase Atp2b1a regulates bone mineralization in zebrafish. Go W, et al. Bone, 2013 May. PMID 23353107
  5. BDNF-TrkB axis regulates migration of the lateral line primordium and modulates the maintenance of mechanoreceptor progenitors. Gasanov EV, et al. PLoS One, 2015. PMID 25751404, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Activity of Atp2b1a is required to facilitate calcification of the developing pharyngeal teeth by the dental epithelium.
    Title: Plasma membrane Ca(2+) ATPase Atp2b1a regulates bone mineralization in zebrafish.
  2. Atp2b1a functions during progenitor cell proliferation and hair cell differentiation
    Title: atp2b1a regulates Ca(2+) export during differentiation and regeneration of mechanosensory hair cells in zebrafish.
  3. Atp2b1a plays an important role for normal development of the auditory and vestibular system as well as calcium transport in the inner ear of zebrafish.
    Title: Plasma membrane calcium ATPase required for semicircular canal formation and otolith growth in the zebrafish inner ear.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type calcium transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables P-type calcium transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bone mineralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within bone morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inner ear receptor cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within otolith development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within posterior lateral line neuromast development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tooth mineralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
plasma membrane calcium-transporting ATPase 1
Names
ATPase, Ca++ transporting, plasma membrane 1a
plasma membrane calcium ATPase 1
NP_001038222.1
XP_009298531.1
XP_021330639.1
XP_021330640.1
XP_021330641.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044757.1 → NP_001038222.1  plasma membrane calcium-transporting ATPase 1

    See identical proteins and their annotated locations for NP_001038222.1

    Status: PROVISIONAL

    Source sequence(s)
    BX649423
    UniProtKB/TrEMBL
    B7ZVL0, F6PDY7
    Related
    ENSDARP00000072130.5, ENSDART00000077664.7
    Conserved Domains (7) summary
    TIGR01517
    Location:10 → 1064
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam00122
    Location:191 → 464
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:880 → 1058
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:49 → 116
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12424
    Location:1105 → 1154
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam12710
    Location:687 → 806
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:525 → 611
    Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    16076719..16124431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021474964.2 → XP_021330639.1  plasma membrane calcium-transporting ATPase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q0B2
    Related
    ENSDARP00000109980.2, ENSDART00000128079.3
    Conserved Domains (2) summary
    pfam12424
    Location:1105 → 1182
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    cl27747
    Location:10 → 1064
    E1-E2_ATPase; E1-E2 ATPase

  2. XM_021474965.2 → XP_021330640.1  plasma membrane calcium-transporting ATPase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QB28
    Conserved Domains (2) summary
    pfam12424
    Location:1105 → 1156
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    cl27747
    Location:10 → 1064
    E1-E2_ATPase; E1-E2 ATPase

  3. XM_009300256.4 → XP_009298531.1  plasma membrane calcium-transporting ATPase 1 isoform X1

    See identical proteins and their annotated locations for XP_009298531.1

    UniProtKB/TrEMBL
    A0A8M9Q0B2
    Conserved Domains (2) summary
    pfam12424
    Location:1105 → 1182
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    cl27747
    Location:10 → 1064
    E1-E2_ATPase; E1-E2 ATPase

  4. XM_021474966.2 → XP_021330641.1  plasma membrane calcium-transporting ATPase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M9Q5T9
    Conserved Domains (2) summary
    pfam12424
    Location:1105 → 1191
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    cl27747
    Location:10 → 1064
    E1-E2_ATPase; E1-E2 ATPase
Nucleotide Protein Strain
Heading Accession and Version

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