prom1b prominin 1 b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prom1bprovided by ZNC
Official Full Name: prominin 1 bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031003-1
See related: Ensembl:ENSDARG00000034007 AllianceGenome:ZFIN:ZDB-GENE-031003-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: proml2
Summary: Predicted to enable cholesterol binding activity. Acts upstream of or within photoreceptor cell outer segment organization. Located in apical plasma membrane. Is expressed in nervous system; otic vesicle; and testis. Human ortholog(s) of this gene implicated in cone-rod dystrophy 12; retinal macular dystrophy 2; and retinitis pigmentosa 41. Orthologous to human PROM1 (prominin 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (22712925..22757193, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (22022186..22066472, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In addition to conserved expression of prominin-1 in photoreceptors, significant prominin-1-expressing non-photoreceptor retinal cell populations are present in the vertebrate eye.[Prominin-1]
Title: Distinct and conserved prominin-1/CD133-positive retinal cell populations identified across species.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cholesterol binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within photoreceptor cell outer segment organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus membrane	IEA Inferred from Electronic Annotation more info
is_active_in prominosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prominin 1 b

Names: prominin-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198071.2 → NP_932337.2 prominin 1 b precursor

Status: VALIDATED

Source sequence(s)

BX908795, FP245458

Related

ENSDARP00000112980.1, ENSDART00000134719.3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

22712925..22757193 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005170913.4 → XP_005170970.1 prominin 1 b isoform X1

UniProtKB/TrEMBL

A0A8M2BI60, Q90WI3

Conserved Domains (1) summary

pfam05478
Location:37 → 851

Prominin; Prominin