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KIF11 kinesin family member 11 [ Homo sapiens (human) ]

Gene ID: 3832, updated on 28-Oct-2024

Summary

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Official Symbol
KIF11provided by HGNC
Official Full Name
kinesin family member 11provided by HGNC
Primary source
HGNC:HGNC:6388
See related
Ensembl:ENSG00000138160 MIM:148760; AllianceGenome:HGNC:6388
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EG5; HKSP; KNSL1; MCLMR; TRIP5
Summary
This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 9.9), bone marrow (RPKM 8.6) and 18 other tissues See more
Orthologs
mouse all
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Genomic context

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See KIF11 in Genome Data Viewer
Location:
10q23.33
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (92593130..92655395)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (93472467..93534736)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (94352887..94415152)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902484 Neighboring gene insulin degrading enzyme Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3771 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3774 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:94352873-94353624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:94357207-94357722 Neighboring gene ribosomal protein L11 pseudogene 4 Neighboring gene uncharacterized LOC124902594 Neighboring gene RNA, 7SL, cytoplasmic 644, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells. Yin Y, et al. Leuk Lymphoma, 2015 Jun. PMID 25146433
  2. KIF11 mutations are a common cause of autosomal dominant familial exudative vitreoretinopathy. Hu H, et al. Br J Ophthalmol, 2016 Feb. PMID 26472404
  3. Overexpression of Eg5 correlates with high grade astrocytic neoplasm. Liu L, et al. J Neurooncol, 2016 Jan. PMID 26456023
  4. The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma. Venere M, et al. Sci Transl Med, 2015 Sep 9. PMID 26355032, Free PMC Article
  5. A Novel Eg5 Inhibitor (LY2523355) Causes Mitotic Arrest and Apoptosis in Cancer Cells and Shows Potent Antitumor Activity in Xenograft Tumor Models. Ye XS, et al. Mol Cancer Ther, 2015 Nov. PMID 26304237

See all (302) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Eg5 UFMylation promotes spindle organization during mitosis.
    Title: Eg5 UFMylation promotes spindle organization during mitosis.
  2. Mitotic Functions and Characters of KIF11 in Cancers.
    Title: Mitotic Functions and Characters of KIF11 in Cancers.
  3. Human kinesin-5 KIF11 drives the helical motion of anti-parallel and parallel microtubules around each other.
    Title: Human kinesin-5 KIF11 drives the helical motion of anti-parallel and parallel microtubules around each other.
  4. KIF11 serves as a cell cycle mediator in childhood acute lymphoblastic leukemia.
    Title: KIF11 serves as a cell cycle mediator in childhood acute lymphoblastic leukemia.
  5. UHRF1 promotes spindle assembly and chromosome congression by catalyzing EG5 polyubiquitination.
    Title: UHRF1 promotes spindle assembly and chromosome congression by catalyzing EG5 polyubiquitination.
  6. ASPM promotes migration and invasion of anaplastic thyroid carcinoma by stabilizing KIF11.
    Title: ASPM promotes migration and invasion of anaplastic thyroid carcinoma by stabilizing KIF11.
  7. Whole exome sequencing revealed novel pathogenic variants in Vietnamese patients with FEVR.
    Title: Whole exome sequencing revealed novel pathogenic variants in Vietnamese patients with FEVR.
  8. KIF11 As a Potential Pan-Cancer Immunological Biomarker Encompassing the Disease Staging, Prognoses, Tumor Microenvironment, and Therapeutic Responses.
    Title: KIF11 As a Potential Pan-Cancer Immunological Biomarker Encompassing the Disease Staging, Prognoses, Tumor Microenvironment, and Therapeutic Responses.
  9. A non-mitotic role for Eg5 in regulating cilium formation and sonic hedgehog signaling.
    Title: A non-mitotic role for Eg5 in regulating cilium formation and sonic hedgehog signaling.
  10. Overexpression of kif11 is a poor prognostic factor in clear cell renal cell carcinoma.
    Title: Overexpression of kif11 is a poor prognostic factor in clear cell renal cell carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (146)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
MedGen: C1835265 OMIM: 152950 GeneReviews: Not available
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Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2013-08-01)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2013-08-01)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat modulates EG5 activity allosterically by blocking ADP release from EG5. Residue K85 in EG5 is important for Tat-mediated suppression of EG5 activity and Tat-induced apoptosis during mitotic arrest PubMed
tat Pull-down/immunoprecipitation assays demonstrate that HIV-1 Tat interacts with EG5 in cells. The carboxyl-terminal domain (residues 73-101) of Tat and the amino-terminal half (residues 1-517) of EG5 are involved in the interaction between Tat and EG5 PubMed
Vif vif HIV Vif interacts with KIF11 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity TAS
Traceable Author Statement
more info
 PubMed 
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in mitotic centrosome separation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic centrosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spindle elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of kinesin complex TAS
Traceable Author Statement
more info
 PubMed 
located_in membrane HDA PubMed 
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kinesin-like protein KIF11
Names
TR-interacting protein 5
TRIP-5
kinesin-like protein 1
kinesin-like spindle protein HKSP
kinesin-related motor protein Eg5
thyroid receptor-interacting protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032580.1 RefSeqGene

    Range
    5063..67328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004523.4 → NP_004514.2  kinesin-like protein KIF11

    See identical proteins and their annotated locations for NP_004514.2

    Status: REVIEWED

    Source sequence(s)
    AA504625, BC136474, BM742618, CU446438, DB078134
    Consensus CDS
    CCDS7422.1
    UniProtKB/Swiss-Prot
    A0AV49, B2RMV3, P52732, Q15716, Q5VWX0
    UniProtKB/TrEMBL
    B2RAM6
    Related
    ENSP00000260731.3, ENST00000260731.5
    Conserved Domains (3) summary
    smart00129
    Location:18 → 366
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01364
    Location:16 → 368
    KISc_BimC_Eg5; Kinesin motor domain, BimC/Eg5 spindle pole proteins
    pfam13931
    Location:916 → 1053
    Microtub_bind; Kinesin-associated microtubule-binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    92593130..92655395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    93472467..93534736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52732.2 GenPept UniProtKB/Swiss-Prot:P52732

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