U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

lipg lipase, endothelial [ Danio rerio (zebrafish) ]

Gene ID: 393096, updated on 2-Nov-2024

Summary

Official Symbol
lipgprovided by ZNC
Official Full Name
lipase, endothelialprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-699
See related
Ensembl:ENSDARG00000031044 AllianceGenome:ZFIN:ZDB-GENE-040426-699
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55345
Summary
Predicted to enable lipoprotein lipase activity and phospholipase A1 activity. Predicted to be involved in several processes, including cholesterol homeostasis; high-density lipoprotein particle remodeling; and triglyceride catabolic process. Predicted to act upstream of or within lipid catabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in myotome; nervous system; neural tube; and notochord. Human ortholog(s) of this gene implicated in cardiovascular system disease; cerebral infarction; coronary artery disease; and myocardial infarction. Orthologous to human LIPG (lipase G, endothelial type). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See lipg in Genome Data Viewer
Location:
chromosome: 8
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (32376936..32386005, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (32367704..32376773, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103911521 Neighboring gene importin 11 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like Neighboring gene epithelial mitogen homolog (mouse)

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Clone Names

  • MGC55345

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipoprotein lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lipoprotein lipase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A1 activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables triacylglycerol lipase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in high-density lipoprotein particle remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
endothelial lipase
NP_956422.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200128.1NP_956422.1  endothelial lipase precursor

    See identical proteins and their annotated locations for NP_956422.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044146
    UniProtKB/TrEMBL
    Q803Y3
    Related
    ENSDARP00000089620.3, ENSDART00000098850.5
    Conserved Domains (3) summary
    TIGR03230
    Location:55488
    lipo_lipase; lipoprotein lipase
    cd00707
    Location:65344
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01758
    Location:351486
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    32376936..32386005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)