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cpne3 copine III [ Danio rerio (zebrafish) ]

Gene ID: 393136, updated on 17-Sep-2024

Summary

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Official Symbol
cpne3provided by ZNC
Official Full Name
copine IIIprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-763
See related
Ensembl:ENSDARG00000104177 AllianceGenome:ZFIN:ZDB-GENE-040426-763
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55622
Summary
Predicted to enable calcium-dependent phospholipid binding activity and receptor tyrosine kinase binding activity. Predicted to be involved in ERBB2 signaling pathway and cellular response to calcium ion. Predicted to be active in plasma membrane. Orthologous to human CPNE3 (copine 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See cpne3 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (31374383..31405794)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (31437168..31468587)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 168 member B Neighboring gene cAMP responsive element modulator b Neighboring gene cyclic nucleotide gated channel subunit beta 3, tandem duplicate 1 Neighboring gene cyclic nucleotide-gated channel beta-3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC55622

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERBB2 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
copine-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200167.1 → NP_956461.1  copine-3

    See identical proteins and their annotated locations for NP_956461.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045408
    UniProtKB/TrEMBL
    Q7ZVU4
    Related
    ENSDARP00000140742.1, ENSDART00000163162.2
    Conserved Domains (3) summary
    cd04047
    Location:139 → 250
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:7 → 125
    C2A_Copine; C2 domain first repeat in Copine
    cd01459
    Location:264 → 513
    vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    31374383..31405794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162840.5 → XP_005162897.1  copine-3 isoform X2

    UniProtKB/TrEMBL
    A0A0R4IUW1, A0A8M2B9S3
    Conserved Domains (3) summary
    cd04047
    Location:139 → 250
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:7 → 125
    C2A_Copine; C2 domain first repeat in Copine
    pfam07002
    Location:309 → 526
    Copine; Copine

  2. XM_005162839.5 → XP_005162896.1  copine-3 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BA35, F1Q9D2
    Related
    ENSDARP00000139825.2, ENSDART00000172335.2
    Conserved Domains (3) summary
    cd04047
    Location:139 → 250
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:7 → 125
    C2A_Copine; C2 domain first repeat in Copine
    pfam07002
    Location:309 → 526
    Copine; Copine

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395182.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    197369..225632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395367.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    203546..232270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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