cdc14b cell division cycle 14B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cdc14bprovided by ZNC
Official Full Name: cell division cycle 14Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-820
See related: Ensembl:ENSDARG00000021483 AllianceGenome:ZFIN:ZDB-GENE-040426-820
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cdc14a; zgc:55844
Summary: Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Acts upstream of or within cilium assembly. Located in condensed chromosome; nucleolus; and spindle. Is expressed in EVL and proliferative region. Orthologous to several human genes including CDC14B (cell division cycle 14B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (1222132..1267247, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (1156389..1201687, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these studies demonstrate for the first time that Cdc14A and Cdc14B have overlapping functions in the ciliogenesis process during zebrafish development.
Title: Functional redundancy between Cdc14 phosphatases in zebrafish ciliogenesis.
Loss of Cdc14B function led to an array of phenotypes, including hydrocephaly, curved body, kidney cysts and left-right asymmetry defects, reminiscent of mutants with defective cilia.
Title: The Cdc14B phosphatase contributes to ciliogenesis in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fb94d11.x1 (e-PCR)
- UniSTS:187665

fc15b09.x1 (e-PCR)
- UniSTS:192717

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of exit from mitosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
NOT located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
NOT located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dual specificity protein phosphatase CDC14B

Names: CDC14 cell division cycle 14 homolog A; CDC14 cell division cycle 14 homolog B

NP_956473.1

EC 3.1.3.48

XP_005166727.1

EC 3.1.3.48

XP_005166728.1

EC 3.1.3.48

XP_005166729.1

EC 3.1.3.48

XP_021333883.1

EC 3.1.3.48

XP_021333884.1

EC 3.1.3.48

XP_068078994.1

EC 3.1.3.48

XP_068078995.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200179.1 → NP_956473.1 dual specificity protein phosphatase CDC14B

See identical proteins and their annotated locations for NP_956473.1

Status: PROVISIONAL

Source sequence(s)

BC045476

UniProtKB/TrEMBL

B2GSL1, Q7ZVN3

Related

ENSDARP00000154397.1, ENSDART00000190371.1

Conserved Domains (2) summary

pfam14671
Location:1 → 93

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:128 → 267

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

1222132..1267247 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005166672.5 → XP_005166729.1 dual specificity protein phosphatase CDC14B isoform X3

UniProtKB/TrEMBL

A0A8M2BE31

Conserved Domains (2) summary

pfam14671
Location:31 → 165

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:200 → 339

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
XM_005166670.5 → XP_005166727.1 dual specificity protein phosphatase CDC14B isoform X1

See identical proteins and their annotated locations for XP_005166727.1

UniProtKB/TrEMBL

A0A8M2BE48

Conserved Domains (2) summary

pfam14671
Location:29 → 166

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:200 → 339

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
XM_068222894.1 → XP_068078995.1 dual specificity protein phosphatase CDC14B isoform X5

Related

ENSDARP00000124917.1, ENSDART00000149924.3
XM_068222893.1 → XP_068078994.1 dual specificity protein phosphatase CDC14B isoform X4
XM_005166671.5 → XP_005166728.1 dual specificity protein phosphatase CDC14B isoform X2

UniProtKB/TrEMBL

A0A8M2BE70

Conserved Domains (2) summary

pfam14671
Location:20 → 154

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:189 → 328

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
XM_021478208.2 → XP_021333883.1 dual specificity protein phosphatase CDC14B isoform X1

UniProtKB/TrEMBL

A0A8M2BE48

Conserved Domains (2) summary

pfam14671
Location:29 → 166

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:200 → 339

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
XM_021478209.2 → XP_021333884.1 dual specificity protein phosphatase CDC14B isoform X6

UniProtKB/TrEMBL

A0A8M9Q9K5

Conserved Domains (2) summary

pfam14671
Location:29 → 166

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:200 → 339

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...