U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

herpud2 HERPUD family member 2 [ Danio rerio (zebrafish) ]

Gene ID: 393157, updated on 12-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
herpud2provided by ZNC
Official Full Name
HERPUD family member 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-868
See related
Ensembl:ENSDARG00000021033 AllianceGenome:ZFIN:ZDB-GENE-040426-868
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56020; zgc:76968
Summary
Predicted to be involved in endoplasmic reticulum unfolded protein response. Predicted to act upstream of or within response to unfolded protein. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human HERPUD2 (HERPUD family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See herpud2 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (42481475..42494345)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (42577717..42590587)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487963 Neighboring gene protein kinase-like domain containing Neighboring gene T-box transcription factor 20 Neighboring gene uncharacterized LOC137487853

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Tbx20 Is an Essential Regulator of Embryonic Heart Growth in Zebrafish. Just S, et al. PLoS One, 2016. PMID 27907103, Free PMC Article
  2. PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation. Gao H, et al. Hum Mol Genet, 2010 Jan 1. PMID 19801576
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PRKCSH functions as a chaperone-like molecule, which prevents endoplasmic reticulum-associated degradation of TRPP2.
    Title: PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC56020

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200188.1 → NP_956482.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein

    See identical proteins and their annotated locations for NP_956482.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045865
    UniProtKB/Swiss-Prot
    Q6NYI0, Q7ZVH0
    Related
    ENSDARP00000038769.6, ENSDART00000037401.7
    Conserved Domains (2) summary
    cd01790
    Location:9 → 87
    Herp_N; Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain protein
    smart00213
    Location:10 → 87
    UBQ; Ubiquitin homologues

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    42481475..42494345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021466640.2 → XP_021322315.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein isoform X1

    UniProtKB/Swiss-Prot
    Q6NYI0, Q7ZVH0
    UniProtKB/TrEMBL
    A0A8M9PM99
    Conserved Domains (1) summary
    cd01790
    Location:9 → 87
    Herp_N; Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NYI0.1 GenPept UniProtKB/Swiss-Prot:Q6NYI0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools