mios missing oocyte, meiosis regulator, homolog (Drosophila) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: miosprovided by ZNC
Official Full Name: missing oocyte, meiosis regulator, homolog (Drosophila)provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-856
See related: Ensembl:ENSDARG00000102587 AllianceGenome:ZFIN:ZDB-GENE-040426-856
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55958
Summary: Acts upstream of or within heart contraction. Predicted to be located in lysosomal membrane. Predicted to be active in cytoplasm. Is expressed in heart and heart tube. Orthologous to human MIOS (meiosis regulator for oocyte development). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (47272823..47301376, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (47326561..47366439, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component Mios.
Title: Rbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component Mios.

Submit: New GeneRIF Correction

General gene information

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Markers

fi38e08.x1 (e-PCR)
- UniSTS:197427

z44736 (e-PCR), detects polymorphism
- UniSTS:238535

fb79a12.y1 (e-PCR)
- UniSTS:191463

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to nutrient levels	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within venous blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of GATOR2 complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GATOR2 complex protein MIOS

Names: GATOR complex protein MIOS; WD repeat-containing protein mio

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201333.1 → NP_958490.1 GATOR2 complex protein MIOS

See identical proteins and their annotated locations for NP_958490.1

Status: PROVISIONAL

Source sequence(s)

BC047198

UniProtKB/Swiss-Prot

Q802U2

Related

ENSDARP00000132748.2, ENSDART00000169697.3

Conserved Domains (4) summary

COG2319
Location:98 → 370

WD40; WD40 repeat [General function prediction only]

sd00039
Location:65 → 106

7WD40; WD40 repeat [structural motif]

cl02567
Location:113 → 299

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl24077
Location:740 → 861

Zn_ribbon_17; Zinc-ribbon, C4HC2 type