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kif18a kinesin family member 18A [ Danio rerio (zebrafish) ]

Gene ID: 393209, updated on 19-Jun-2024

Summary

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Official Symbol
kif18aprovided by ZNC
Official Full Name
kinesin family member 18Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-862
See related
Ensembl:ENSDARG00000008022 AllianceGenome:ZFIN:ZDB-GENE-040426-862
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55995; CH211-12J24.1
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in microtubule depolymerization; microtubule-based movement; and mitotic sister chromatid segregation. Predicted to be part of kinesin complex. Predicted to be active in mitotic spindle astral microtubule; mitotic spindle midzone; and nucleus. Orthologous to several human genes including KIF18A (kinesin family member 18A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See kif18a in Genome Data Viewer
Location:
chromosome: 7
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (31976764..32020790, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (31705614..31749640, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103911387 Neighboring gene lin-7 homolog C (C. elegans) Neighboring gene brain-derived neurotrophic factor Neighboring gene methyltransferase 15, mitochondrial 12S rRNA N4-cytidine Neighboring gene uncharacterized LOC103911388

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC55995

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitotic spindle astral microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF18A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200239.1 → NP_956533.1  kinesin-like protein KIF18A

    See identical proteins and their annotated locations for NP_956533.1

    Status: PROVISIONAL

    Source sequence(s)
    BC047799
    UniProtKB/TrEMBL
    Q7ZUW9
    Related
    ENSDARP00000022797.8, ENSDART00000023568.10
    Conserved Domains (2) summary
    smart00129
    Location:9 → 354
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01370
    Location:9 → 353
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    31976764..32020790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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