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mia2 MIA SH3 domain ER export factor 2 [ Danio rerio (zebrafish) ]

Gene ID: 393281, updated on 28-Oct-2024

Summary

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Official Symbol
mia2provided by ZNC
Official Full Name
MIA SH3 domain ER export factor 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-100618-1
See related
AllianceGenome:ZFIN:ZDB-GENE-100618-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ctage5; zgc:56047
Summary
Acts upstream of or within several processes, including embryonic cranial skeleton morphogenesis; lipoprotein transport; and regulation of heart looping. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum exit site and endoplasmic reticulum membrane. Is expressed in central nervous system; hatching gland; liver; and yolk syncytial layer. Orthologous to several human genes including CTAGE15 (CTAGE family member 15); CTAGE6 (CTAGE family member 6); and CTAGE8 (CTAGE family member 8). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
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Genomic context

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See mia2 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (13045350..13083454, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (12891431..12904459, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2, regulatory subunit B'', gamma Neighboring gene family with sequence similarity 177 member A1 Neighboring gene F-box protein 33 Neighboring gene gem (nuclear organelle) associated protein 2 Neighboring gene pinin, desmosome associated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Complementary and divergent functions of zebrafish Tango1 and Ctage5 in tissue development and homeostasis. Clark EM, et al. Mol Biol Cell, 2021 Mar 1. PMID 33439675, Free PMC Article
  2. Genome wide analysis reveals Zic3 interaction with distal regulatory elements of stage specific developmental genes in zebrafish. Winata CL, et al. PLoS Genet, 2013 Oct. PMID 24204288, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Complementary and divergent functions of zebrafish Tango1 and Ctage5 in tissue development and homeostasis.
    Title: Complementary and divergent functions of zebrafish Tango1 and Ctage5 in tissue development and homeostasis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC56047

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lens development in camera-type eye IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within lipoprotein transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within lipoprotein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of heart looping IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of response to endoplasmic reticulum stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cTAGE family member 5
Names
CTAGE family, member 5
melanoma inhibitory activity 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001423208.1 → NP_001410137.1  cTAGE family member 5 precursor

    Status: VALIDATED

    Source sequence(s)
    CU469462

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    13045350..13083454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467326.2 → XP_021323001.1  cTAGE family member 5 isoform X4

    UniProtKB/TrEMBL
    A0A8M9PL56
    Conserved Domains (4) summary
    cd11892
    Location:33 → 105
    SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
    pfam15498
    Location:787 → 869
    Dendrin; Nephrin and CD2AP-binding protein, Dendrin
    pfam15822
    Location:976 → 1030
    MISS; MAPK-interacting and spindle-stabilizing protein-like
    cl25732
    Location:364 → 746
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_021467325.2 → XP_021323000.1  cTAGE family member 5 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PP77
    Conserved Domains (5) summary
    cd11892
    Location:33 → 105
    SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
    pfam15402
    Location:248 → 412
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    pfam15498
    Location:1027 → 1109
    Dendrin; Nephrin and CD2AP-binding protein, Dendrin
    pfam15822
    Location:1216 → 1270
    MISS; MAPK-interacting and spindle-stabilizing protein-like
    cl25732
    Location:604 → 986
    SMC_N; RecF/RecN/SMC N terminal domain

  3. XM_021467324.2 → XP_021322999.1  cTAGE family member 5 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PEL4
    Conserved Domains (5) summary
    cd11892
    Location:33 → 105
    SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
    pfam15498
    Location:1345 → 1427
    Dendrin; Nephrin and CD2AP-binding protein, Dendrin
    pfam15822
    Location:1534 → 1588
    MISS; MAPK-interacting and spindle-stabilizing protein-like
    cl25732
    Location:922 → 1304
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26761
    Location:257 → 730
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

  4. XM_021467321.2 → XP_021322996.1  cTAGE family member 5 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PEK9, A0A8M9PL51
    Conserved Domains (5) summary
    cd11892
    Location:33 → 105
    SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
    COG2931
    Location:1025 → 1295
    COG2931; Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism]
    pfam15822
    Location:2507 → 2561
    MISS; MAPK-interacting and spindle-stabilizing protein-like
    cl25732
    Location:1937 → 2319
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26761
    Location:257 → 730
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_200311.1: Suppressed sequence

    Description
    NM_200311.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: CTAGE5 (GeneID:4253).
Nucleotide Protein Strain
Heading Accession and Version

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