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irs2a insulin receptor substrate 2a [ Danio rerio (zebrafish) ]

Gene ID: 393285, updated on 28-Oct-2024

Summary

Official Symbol
irs2aprovided by ZNC
Official Full Name
insulin receptor substrate 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-975
See related
Ensembl:ENSDARG00000037099 AllianceGenome:ZFIN:ZDB-GENE-040426-975
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56306
Summary
Predicted to enable insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Acts upstream of or within response to hypoxia. Predicted to be active in cytosol and plasma membrane. Is expressed in germ ring; head; and liver. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IRS2 (insulin receptor substrate 2). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

See irs2a in Genome Data Viewer
Location:
chromosome: 1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (29211502..29229473)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (28407609..28424449)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene zgc:173948 Neighboring gene cysteinyl-tRNA synthetase 2, mitochondrial Neighboring gene ligase IV, DNA, ATP-dependent Neighboring gene NALCN channel auxiliary factor 1a

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Clone Names

  • MGC56306

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables insulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables insulin receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol 3-kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
insulin receptor substrate 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200315.1NP_956609.1  insulin receptor substrate 2a

    See identical proteins and their annotated locations for NP_956609.1

    Status: PROVISIONAL

    Source sequence(s)
    BC050518
    UniProtKB/TrEMBL
    Q7ZU74
    Related
    ENSDARP00000053923.4, ENSDART00000053924.5
    Conserved Domains (3) summary
    cd01204
    Location:157260
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:24126
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
    pfam00169
    Location:25123
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    29211502..29229473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021466764.2XP_021322439.1  insulin receptor substrate 2a isoform X1

    UniProtKB/TrEMBL
    A0A8M9PD89
    Conserved Domains (2) summary
    cd01204
    Location:157260
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:24126
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain

RNA

  1. XR_002455723.2 RNA Sequence