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pacc1 proton activated chloride channel 1 [ Danio rerio (zebrafish) ]

Gene ID: 393429, updated on 18-Sep-2024

Summary

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Official Symbol
pacc1provided by ZNC
Official Full Name
proton activated chloride channel 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1173
See related
Ensembl:ENSDARG00000012271 AllianceGenome:ZFIN:ZDB-GENE-040426-1173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
PAC; fPAC; tmem206; zgc:63579
Summary
Enables pH-gated chloride channel activity. Involved in chloride transport. Acts upstream of or within chloride transmembrane transport. Predicted to be integral component of plasma membrane. Predicted to be part of chloride channel complex. Orthologous to human PACC1 (proton activated chloride channel 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See pacc1 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (45378908..45386823, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (45395656..45403571, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene calpain 3a, (p94) Neighboring gene zinc finger protein 106a Neighboring gene neudesin neurotrophic factor Neighboring gene T cell activation RhoGTPase activating protein a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel. Yang J, et al. Science, 2019 Apr 26. PMID 31023925, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC63579

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
enables pH-gated chloride channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chloride transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within chloride transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
proton-activated chloride channel
Names
transmembrane protein 206

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291762.1 → NP_001278691.1  proton-activated chloride channel

    Status: VALIDATED

    Source sequence(s)
    BX322589
    UniProtKB/Swiss-Prot
    Q7SY31
    UniProtKB/TrEMBL
    A0A8M1P0Q6, X1WG42
    Related
    ENSDARP00000129197.2, ENSDART00000156002.3
    Conserved Domains (1) summary
    pfam15122
    Location:56 → 350
    TMEM206; TMEM206 protein family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    45378908..45386823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_200457.1: Suppressed sequence

    Description
    NM_200457.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7SY31.1 GenPept UniProtKB/Swiss-Prot:Q7SY31

Gene LinkOut

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