mvb12a multivesicular body subunit 12A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mvb12aprovided by ZNC
Official Full Name: multivesicular body subunit 12Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1240
See related: AllianceGenome:ZFIN:ZDB-GENE-040426-1240
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fam125a; zgc:63691; si:ch1073-286c18.3
Summary: Predicted to enable SH3 domain binding activity. Predicted to be involved in several processes, including endosome to lysosome transport via multivesicular body sorting pathway; receptor catabolic process; and regulation of epidermal growth factor receptor signaling pathway. Predicted to act upstream of or within protein transport. Predicted to be located in late endosome membrane. Predicted to be part of ESCRT I complex. Predicted to be active in cytosol. Orthologous to human MVB12A (multivesicular body subunit 12A). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (59237328..59243521, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (58530502..58536695, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endosome to lysosome transport via multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in receptor catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in viral budding	IBA Inferred from Biological aspect of Ancestor more info
involved_in virus maturation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of ESCRT I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT I complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: multivesicular body subunit 12A

Names: ESCRT-I complex subunit MVB12A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200484.1 → NP_956778.1 multivesicular body subunit 12A

See identical proteins and their annotated locations for NP_956778.1

Status: PROVISIONAL

Source sequence(s)

BC055206

UniProtKB/Swiss-Prot

Q7SXX7

Conserved Domains (1) summary

pfam10240
Location:9 → 262

DUF2464; Protein of unknown function (DUF2464)