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dtx3 deltex E3 ubiquitin ligase 3 [ Danio rerio (zebrafish) ]

Gene ID: 393500, updated on 28-Oct-2024

Summary

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Official Symbol
dtx3provided by ZNC
Official Full Name
deltex E3 ubiquitin ligase 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1640
See related
Ensembl:ENSDARG00000025766 AllianceGenome:ZFIN:ZDB-GENE-040426-1640
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
deltex3; fi25g12; zgc:66440; wu:fi25g12
Summary
Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within Notch signaling pathway. Predicted to be located in cytoplasm. Orthologous to human DTX3 (deltex E3 ubiquitin ligase 3). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See dtx3 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (27040128..27050084, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (27113587..27134526, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, beta 3b Neighboring gene Rho family GTPase 1b Neighboring gene prostaglandin E synthase 3a (cytosolic) Neighboring gene major intrinsic protein of lens fiber a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A comparative study of the expression patterns of Fign family members in zebrafish embryonic development. Dong Z, et al. Comp Biochem Physiol B Biochem Mol Biol, 2021 Jan. PMID 33069857
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC66440

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase DTX3
NP_956822.3
XP_005162299.1
XP_005162301.1
XP_009295112.1
XP_068072809.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200528.3 → NP_956822.3  probable E3 ubiquitin-protein ligase DTX3

    Status: VALIDATED

    Source sequence(s)
    CR354433
    UniProtKB/TrEMBL
    A0A8M3AVB3, F1QUJ1
    Related
    ENSDARP00000110688.2, ENSDART00000128718.3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    27040128..27050084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162242.5 → XP_005162299.1  probable E3 ubiquitin-protein ligase DTX3 isoform X1

    See identical proteins and their annotated locations for XP_005162299.1

    UniProtKB/TrEMBL
    A0A8M2B9F2
    Conserved Domains (2) summary
    cd09633
    Location:233 → 365
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd00162
    Location:186 → 225
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  2. XM_009296837.4 → XP_009295112.1  probable E3 ubiquitin-protein ligase DTX3 isoform X1

    See identical proteins and their annotated locations for XP_009295112.1

    UniProtKB/TrEMBL
    A0A8M2B9F2
    Conserved Domains (2) summary
    cd09633
    Location:233 → 365
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd00162
    Location:186 → 225
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  3. XM_068216708.1 → XP_068072809.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

  4. XM_005162244.4 → XP_005162301.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

    See identical proteins and their annotated locations for XP_005162301.1

    UniProtKB/TrEMBL
    A0A2R8Q098, A0A2R8QRQ2, A0A8M3B638, F1R959, Q4G0B5
    Related
    ENSDARP00000107053.2, ENSDART00000124482.4
    Conserved Domains (2) summary
    cd09633
    Location:224 → 356
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd00162
    Location:177 → 216
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395154.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    281548..290021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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