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snx27b sorting nexin 27b [ Danio rerio (zebrafish) ]

Gene ID: 393512, updated on 2-Nov-2024

Summary

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Official Symbol
snx27bprovided by ZNC
Official Full Name
sorting nexin 27bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1529
See related
Ensembl:ENSDARG00000016977 AllianceGenome:ZFIN:ZDB-GENE-040426-1529
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
snx27; zgc:66094; zgc:77922
Summary
Predicted to enable phosphatidylinositol binding activity. Acts upstream of or within axonogenesis. Predicted to be located in membrane. Predicted to be active in early endosome. Orthologous to human SNX27 (sorting nexin 27). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See snx27b in Genome Data Viewer
Location:
chromosome: 16
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (23495608..23525405)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (23580534..23610700)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene ictacalcin Neighboring gene ictacalcin 2 Neighboring gene adenosine deaminase RNA specific Neighboring gene uncharacterized LOC101885210

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. SNX27-FERM-SNX1 complex structure rationalizes divergent trafficking pathways by SNX17 and SNX27. Yong X, et al. Proc Natl Acad Sci U S A, 2021 Sep 7. PMID 34462354, Free PMC Article
  2. An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish. Xu L, et al. Hepatology, 2012 Jun. PMID 22213104
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC66094

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sorting nexin-27b
Names
sorting nexin family member 27
sorting nexin family member 27b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200540.1 → NP_956834.1  sorting nexin-27b

    See identical proteins and their annotated locations for NP_956834.1

    Status: PROVISIONAL

    Source sequence(s)
    BC056315
    UniProtKB/TrEMBL
    Q6P3G2, Q6PHV2
    Related
    ENSDARP00000011221.8, ENSDART00000021092.9
    Conserved Domains (4) summary
    cd06886
    Location:165 → 270
    PX_SNX27; The phosphoinositide binding Phox Homology domain of Sorting Nexin 27
    cd01777
    Location:279 → 365
    SNX27_RA; Ubiquitin domain of SNX27 (sorting nexin protein 27)
    cd00992
    Location:46 → 138
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13338
    Location:430 → 531
    FERM-like_C_SNX27; Atypical FERM-like domain C-lobe of Sorting nexin 27

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    23495608..23525405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158092.5 → XP_005158149.1  sorting nexin-27b isoform X1

    UniProtKB/TrEMBL
    A0A8M2B4E4
    Conserved Domains (4) summary
    cd06886
    Location:165 → 270
    PX_SNX27; The phosphoinositide binding Phox Homology domain of Sorting Nexin 27
    cd01777
    Location:279 → 365
    SNX27_RA; Ubiquitin domain of SNX27 (sorting nexin protein 27)
    cd00992
    Location:46 → 138
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13338
    Location:430 → 531
    FERM-like_C_SNX27; Atypical FERM-like domain C-lobe of Sorting nexin 27
Nucleotide Protein Strain
Heading Accession and Version

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