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tiprl TIP41, TOR signaling pathway regulator-like (S. cerevisiae) [ Danio rerio (zebrafish) ]

Gene ID: 393636, updated on 27-Mar-2024

Summary

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Official Symbol
tiprlprovided by ZNC
Official Full Name
TIP41, TOR signaling pathway regulator-like (S. cerevisiae)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1611
See related
Ensembl:ENSDARG00000032353 AllianceGenome:ZFIN:ZDB-GENE-040426-1611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:66327
Summary
Acts upstream of or within chordate embryonic development and negative regulation of apoptotic process. Predicted to be active in cytosol. Is expressed in blastomere; brain; gut; and liver. Orthologous to human TIPRL (TOR signaling pathway regulator). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See tiprl in Genome Data Viewer
Location:
chromosome: 10
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (15970..22780)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (30617..37427)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene ribosomal oxygenase 2 Neighboring gene crystallin beta-gamma domain containing 3 Neighboring gene SIM bHLH transcription factor 2 Neighboring gene holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Inhibition of MKK7-JNK by the TOR signaling pathway regulator-like protein contributes to resistance of HCC cells to TRAIL-induced apoptosis. Song IS, et al. Gastroenterology, 2012 Nov. PMID 22841785
  2. Tiling histone H3 lysine 4 and 27 methylation in zebrafish using high-density microarrays. Lindeman LC, et al. PLoS One, 2010 Dec 20. PMID 21187971, Free PMC Article
  3. Integrating omics and traditional analyses to profile the synergistic toxicity of graphene oxide and triphenyl phosphate. Zhang X, et al. Environ Pollut, 2020 Aug. PMID 33618456
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC66327

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chordate embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TIP41-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328426.1 → NP_001315355.1  TIP41-like protein

    Status: VALIDATED

    Source sequence(s)
    CABZ01118093
    UniProtKB/TrEMBL
    A0A8M1P4V0, F1QRY4
    Related
    ENSDARP00000040239.5, ENSDART00000040240.6
    Conserved Domains (1) summary
    pfam04176
    Location:59 → 221
    TIP41; TIP41-like family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    15970..22780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_200663.1: Suppressed sequence

    Description
    NM_200663.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

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