U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

abi1a abl-interactor 1a [ Danio rerio (zebrafish) ]

Gene ID: 393711, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
abi1aprovided by ZNC
Official Full Name
abl-interactor 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1701
See related
Ensembl:ENSDARG00000010155 AllianceGenome:ZFIN:ZDB-GENE-040426-1701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
abi1; zgc:73174; wu:fc66g09; wu:fk56a10
Summary
Predicted to enable SH3 domain binding activity and signaling adaptor activity. Predicted to be involved in neuron migration. Predicted to be located in filopodium. Predicted to be part of SCAR complex. Predicted to be active in actin-based cell projection and lamellipodium. Orthologous to human ABI1 (abl interactor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See abi1a in Genome Data Viewer
Location:
chromosome: 24
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (5935413..6012362)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (5906083..5981999)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 64 Neighboring gene acyl-CoA binding domain containing 5a Neighboring gene tripartite motif-containing protein 16-like Neighboring gene prenyl (decaprenyl) diphosphate synthase, subunit 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. Edwards JJ, et al. JACC Basic Transl Sci, 2020 Apr. PMID 32368696, Free PMC Article
  2. Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish. Seiler C, et al. PLoS One, 2015. PMID 26161877, Free PMC Article
  3. A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants. Ma Z, et al. Sci Rep, 2017 Sep 4. PMID 28871129, Free PMC Article
  4. Evolution of gene function and regulatory control after whole-genome duplication: comparative analyses in vertebrates. Kassahn KS, et al. Genome Res, 2009 Aug. PMID 19439512, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC73174

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in neuron migration IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCAR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in actin-based cell projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in filopodium IEA
Inferred from Electronic Annotation
more info
  
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
abl interactor 1a
Names
abl-interactor 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328427.1 → NP_001315356.1  abl interactor 1a

    Status: VALIDATED

    Source sequence(s)
    CR385039
    UniProtKB/TrEMBL
    A0A8M1PA08, F1R187
    Related
    ENSDARP00000116601.1, ENSDART00000131768.2
    Conserved Domains (3) summary
    cd11971
    Location:425 → 483
    SH3_Abi1; Src homology 3 domain of Abl Interactor 1
    pfam07815
    Location:93 → 165
    Abi_HHR; Abl-interactor HHR
    cl23725
    Location:405 → 435
    Glyco_hydro_1; Glycosyl hydrolase family 1

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    5935413..6012362
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162496.5 → XP_005162553.1  abl interactor 1a isoform X5

    UniProtKB/TrEMBL
    A0A8M2B9B3
    Conserved Domains (3) summary
    cd11971
    Location:365 → 423
    SH3_Abi1; Src homology 3 domain of Abl Interactor 1
    pfam07815
    Location:93 → 165
    Abi_HHR; Abl-interactor HHR
    cl23725
    Location:345 → 375
    Glyco_hydro_1; Glycosyl hydrolase family 1

  2. XM_005162499.5 → XP_005162556.1  abl interactor 1a isoform X7

    UniProtKB/TrEMBL
    A0A8M2B9D2
    Conserved Domains (3) summary
    pfam07815
    Location:93 → 165
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:331 → 389
    SH3; Src Homology 3 domain superfamily
    cl23725
    Location:311 → 341
    Glyco_hydro_1; Glycosyl hydrolase family 1

  3. XM_009297227.4 → XP_009295502.1  abl interactor 1a isoform X1

    UniProtKB/TrEMBL
    A0A8M3AND6
    Conserved Domains (3) summary
    cd11971
    Location:464 → 522
    SH3_Abi1; Src homology 3 domain of Abl Interactor 1
    pfam07815
    Location:93 → 162
    Abi_HHR; Abl-interactor HHR
    cl23725
    Location:444 → 474
    Glyco_hydro_1; Glycosyl hydrolase family 1

  4. XM_009297229.4 → XP_009295504.1  abl interactor 1a isoform X4

    UniProtKB/TrEMBL
    A0A8M3AP19
    Conserved Domains (3) summary
    cd11971
    Location:370 → 428
    SH3_Abi1; Src homology 3 domain of Abl Interactor 1
    pfam07815
    Location:93 → 162
    Abi_HHR; Abl-interactor HHR
    cl23725
    Location:350 → 380
    Glyco_hydro_1; Glycosyl hydrolase family 1

  5. XM_005162489.5 → XP_005162546.1  abl interactor 1a isoform X3

    UniProtKB/TrEMBL
    A0A2R8QEN6, A0A8M2B9D1
    Related
    ENSDARP00000150366.1, ENSDART00000191989.1
    Conserved Domains (3) summary
    cd11971
    Location:430 → 488
    SH3_Abi1; Src homology 3 domain of Abl Interactor 1
    pfam07815
    Location:93 → 162
    Abi_HHR; Abl-interactor HHR
    cl23725
    Location:410 → 440
    Glyco_hydro_1; Glycosyl hydrolase family 1

  6. XM_005162498.5 → XP_005162555.1  abl interactor 1a isoform X6

    UniProtKB/TrEMBL
    A0A2R8Q1F3, A0A8M2B9J6
    Related
    ENSDARP00000146940.1, ENSDART00000185932.1
    Conserved Domains (3) summary
    pfam07815
    Location:93 → 162
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:336 → 394
    SH3; Src Homology 3 domain superfamily
    cl23725
    Location:316 → 346
    Glyco_hydro_1; Glycosyl hydrolase family 1

  7. XM_009297228.4 → XP_009295503.1  abl interactor 1a isoform X2

    UniProtKB/TrEMBL
    A0A8M3B6H8
    Conserved Domains (3) summary
    cd11971
    Location:459 → 517
    SH3_Abi1; Src homology 3 domain of Abl Interactor 1
    pfam07815
    Location:93 → 165
    Abi_HHR; Abl-interactor HHR
    cl23725
    Location:439 → 469
    Glyco_hydro_1; Glycosyl hydrolase family 1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_200738.1: Suppressed sequence

    Description
    NM_200738.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.