xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: xrcc4provided by ZNC
Official Full Name: X-ray repair complementing defective repair in Chinese hamster cells 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1755
See related: Ensembl:ENSDARG00000010732 AllianceGenome:ZFIN:ZDB-GENE-040426-1755
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:73312
Summary: Predicted to enable DNA binding activity. Predicted to be involved in DNA metabolic process and response to X-ray. Predicted to act upstream of or within DNA recombination and double-strand break repair. Predicted to be located in nucleus. Predicted to be part of DNA ligase IV complex and DNA-dependent protein kinase-DNA ligase 4 complex. Human ortholog(s) of this gene implicated in multiple myeloma; salivary gland adenoid cystic carcinoma; and salivary gland carcinoma. Orthologous to human XRCC4 (X-ray repair cross complementing 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (43117661..43183980)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (43289296..43355600)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA ligation involved in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA recombination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within double-strand break repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via nonhomologous end joining	IBA Inferred from Biological aspect of Ancestor more info
involved_in immunoglobulin V(D)J recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to X-ray	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of DNA ligase IV complex	IBA Inferred from Biological aspect of Ancestor more info
part_of DNA-dependent protein kinase-DNA ligase 4 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA repair protein XRCC4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200786.1 → NP_957080.1 DNA repair protein XRCC4

See identical proteins and their annotated locations for NP_957080.1

Status: PROVISIONAL

Source sequence(s)

BC059635

UniProtKB/TrEMBL

A0A8M1PBS5, Q6PBP2

Related

ENSDARP00000025376.8, ENSDART00000024644.9

Conserved Domains (1) summary

pfam06632
Location:5 → 355

XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

43117661..43183980

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009305682.3 → XP_009303957.1 DNA repair protein XRCC4 isoform X1

UniProtKB/TrEMBL

A0A2R8RHK7, A0A8M3B6L4

Related

ENSDARP00000144821.1, ENSDART00000186932.1

Conserved Domains (1) summary

pfam06632
Location:6 → 356

XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4