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tmem126a transmembrane protein 126A [ Danio rerio (zebrafish) ]

Gene ID: 393771, updated on 2-Nov-2024

Summary

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Official Symbol
tmem126aprovided by ZNC
Official Full Name
transmembrane protein 126Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1770
See related
Ensembl:ENSDARG00000014506 AllianceGenome:ZFIN:ZDB-GENE-040426-1770
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:73348
Summary
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 29 and optic atrophy 7. Orthologous to several human genes including TMEM126A (transmembrane protein 126A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See tmem126a in Genome Data Viewer
Location:
chromosome: 10
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (29269998..29272757, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (29383373..29386132, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin-like 2a Neighboring gene CREB/ATF bZIP transcription factor Neighboring gene discs, large homolog 2 (Drosophila) Neighboring gene uncharacterized LOC137496592 Neighboring gene HEPACAM family member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC73348

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transmembrane protein 126A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328432.1 → NP_001315361.1  transmembrane protein 126A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    EH441595, EH463071, EH493909, EH588251, EH594896
    UniProtKB/TrEMBL
    A0A2R8QM83, A0A8M1PFS9
    Related
    ENSDARP00000148912.1, ENSDART00000184594.1
    Conserved Domains (1) summary
    pfam07114
    Location:20 → 195
    DUF1370; Protein of unknown function (DUF1370)

  2. NM_200798.2 → NP_957092.2  transmembrane protein 126A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    EH463071, EH493909, EH588251, EH594896
    UniProtKB/TrEMBL
    A0A2R8QM83, A0A8M1PFS9
    Related
    ENSDARP00000153689.1, ENSDART00000185371.1
    Conserved Domains (1) summary
    pfam07114
    Location:20 → 195
    DUF1370; Protein of unknown function (DUF1370)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    29269998..29272757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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