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fkbp1b FKBP prolyl isomerase 1B [ Danio rerio (zebrafish) ]

Gene ID: 393785, updated on 18-Sep-2024

Summary

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Official Symbol
fkbp1bprovided by ZNC
Official Full Name
FKBP prolyl isomerase 1Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1785
See related
Ensembl:ENSDARG00000052625 AllianceGenome:ZFIN:ZDB-GENE-040426-1785
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:73381; si:dkeyp-115a10.1
Summary
Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding and protein peptidyl-prolyl isomerization. Predicted to be active in cytoplasm. Is expressed in basal plate midbrain region; brain; cranial ganglion; and myotome. Human ortholog(s) of this gene implicated in Graves' disease. Orthologous to several human genes including FKBP1B (FKBP prolyl isomerase 1B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See fkbp1b in Genome Data Viewer
Location:
chromosome: 20
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (44464345..44496234, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (44566339..44598218, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene opsin 8, group member b Neighboring gene methylmalonyl CoA mutase Neighboring gene WD repeat and coiled coil containing Neighboring gene MFSD2 lysolipid transporter B, sphingolipid

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison. Holland EB, et al. Aquat Toxicol, 2017 Nov. PMID 28942070, Free PMC Article
  2. Embryonic temperature affects muscle fibre recruitment in adult zebrafish: genome-wide changes in gene and microRNA expression associated with the transition from hyperplastic to hypertrophic growth phenotypes. Johnston IA, et al. J Exp Biol, 2009 Jun. PMID 19482995
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC73381

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sarcoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP1B
Names
FK506 binding protein 1b
NP_957106.1
XP_068071496.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200812.2 → NP_957106.1  peptidyl-prolyl cis-trans isomerase FKBP1B

    See identical proteins and their annotated locations for NP_957106.1

    Status: VALIDATED

    Source sequence(s)
    BX664630, CR545466
    UniProtKB/TrEMBL
    A0A8M1PBT7, Q6PBJ1
    Related
    ENSDARP00000021881.6, ENSDART00000012229.8
    Conserved Domains (1) summary
    COG0545
    Location:2 → 106
    FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    44464345..44496234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068215395.1 → XP_068071496.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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