amph amphiphysin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: amphprovided by ZNC
Official Full Name: amphiphysinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1711
See related: Ensembl:ENSDARG00000007663 AllianceGenome:ZFIN:ZDB-GENE-040426-1711
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:73193; wu:fq25h04
Summary: Predicted to enable phospholipid binding activity. Predicted to be involved in synaptic vesicle endocytosis. Located in cytoplasm. Is expressed in several structures, including fin; gonad; heart; nervous system; and neural tube. Orthologous to human AMPH (amphiphysin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (31891226..31937005, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (31908008..31953802, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CDKL5 phosphorylates amphiphysin 1 at Ser-285 and Ser-293 sites.Splice variants of Amph1 showed different spatial and temporal expressions.
Title: Expression analyses of splice variants of zebrafish cyclin-dependent kinase-like 5 and its substrate, amphiphysin 1.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: amphiphysin

Names: amphiphysin1a; amphiphysin1b; amphiphysin1c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.