panx1a pannexin 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: panx1aprovided by ZNC
Official Full Name: pannexin 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-766
See related: Ensembl:ENSDARG00000025285 AllianceGenome:ZFIN:ZDB-GENE-040426-766
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: panx1; zgc:55631
Summary: Enables gap junction hemi-channel activity and voltage-gated channel activity. Acts upstream of or within G protein-coupled dopamine receptor signaling pathway; transmembrane transport; and visual perception. Located in ruffle membrane. Is expressed in several structures, including heart; integument; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human PANX1 (pannexin 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 15

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (2475896..2489934)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (2512324..2526362)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling.
Title: Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling.
Role of an Aromatic-Aromatic Interaction in the Assembly and Trafficking of the Zebrafish Panx1a Membrane Channel.
Title: Role of an Aromatic-Aromatic Interaction in the Assembly and Trafficking of the Zebrafish Panx1a Membrane Channel.
Extracellular ATP hydrolysis via NTPDase1 action inhibits synaptic transmission by pannexin 1-mediated increase in pH buffering of the synaptic cleft.
Title: Extracellular ATP hydrolysis inhibits synaptic transmission by increasing ph buffering in the synaptic cleft.
The existence of two Panx1 proteins in zebrafish displaying distinct tissue distribution, protein modification and electrophysiological properties, suggests that both proteins fulfill different functions in vivo.
Title: Pannexin1 channel proteins in the zebrafish retina have shared and unique properties.
The function of panx1 channel is significantly reduced following mutation of a single cysteine residue (C282W) in the fourth transmembrane region of panx1.
Title: Replacement of a single cysteine in the fourth transmembrane region of zebrafish pannexin 1 alters hemichannel gating behavior.
zfPanx1 displays properties similar to its mammalian homologues and can potentially play an important role in functions of the outer retina.
Title: Pannexin1 in the outer retina of the zebrafish, Danio rerio.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables channel activity	IDA Inferred from Direct Assay more info	PubMed
enables channel activity	IEA Inferred from Electronic Annotation more info
enables gap junction hemi-channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated channel activity	IDA Inferred from Direct Assay more info	PubMed
enables wide pore channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables wide pore channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled dopamine receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic cation transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of interleukin-1 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within visual perception	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: pannexin-1a

Names: pannexin 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.