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dnm1l dynamin 1-like [ Danio rerio (zebrafish) ]

Gene ID: 393896, updated on 2-Nov-2024

Summary

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Official Symbol
dnm1lprovided by ZNC
Official Full Name
dynamin 1-likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1556
See related
Ensembl:ENSDARG00000015006 AllianceGenome:ZFIN:ZDB-GENE-040426-1556
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
drp1; zgc:66163
Summary
Predicted to enable GTPase activity; microtubule binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including mitochondrion organization; peroxisome fission; and protein complex oligomerization. Predicted to act upstream of or within rhythmic process. Predicted to be located in cytosol; mitochondrial outer membrane; and peroxisome. Predicted to be active in membrane; microtubule; and mitochondrion. Is expressed in brain and eye. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 1 and optic atrophy 5. Orthologous to human DNM1L (dynamin 1 like). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See dnm1l in Genome Data Viewer
Location:
chromosome: 25
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (20229573..20258638, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (20131919..20160997, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene caldesmon 1b Neighboring gene uncharacterized LOC103909847 Neighboring gene troponin T2d, cardiac Neighboring gene si:dkey-219c3.2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B9a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Optic nerve injury-induced regeneration in the adult zebrafish is accompanied by spatiotemporal changes in mitochondrial dynamics. Beckers A, et al. Neural Regen Res, 2023 Jan. PMID 35799546, Free PMC Article
  2. Dawn and dusk peaks of outer segment phagocytosis, and visual cycle function require Rab28. Moran AL, et al. FASEB J, 2022 May. PMID 35471581, Free PMC Article
  3. Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons. Drerup CM, et al. Elife, 2017 Apr 17. PMID 28414272, Free PMC Article
  4. TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology. Chen S, et al. Mol Cell, 2020 Dec 3. PMID 33171123
  5. Opa1 is required for proper mitochondrial metabolism in early development. Rahn JJ, et al. PLoS One, 2013. PMID 23516612, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC66163

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular distribution of mitochondria IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial fission ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial fragmentation involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peroxisome fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peroxisome fission ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein complex oligomerization ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dynamin-1-like protein
NP_957216.1
XP_005163105.1
XP_005163106.1
XP_005163107.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200922.1 → NP_957216.1  dynamin-1-like protein

    See identical proteins and their annotated locations for NP_957216.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055521
    UniProtKB/Swiss-Prot
    Q7SXN5
    Related
    ENSDARP00000006315.5, ENSDART00000006840.7
    Conserved Domains (4) summary
    cd08771
    Location:23 → 301
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:87 → 684
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:226 → 509
    Dynamin_M; Dynamin central region
    pfam02212
    Location:597 → 685
    GED; Dynamin GTPase effector domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    20229573..20258638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163049.3 → XP_005163106.1  dynamin-1-like protein isoform X2

    UniProtKB/TrEMBL
    A0A140LH30, A0A8M2BA29
    Related
    ENSDARP00000142560.1, ENSDART00000173434.2
    Conserved Domains (4) summary
    cd08771
    Location:23 → 301
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:87 → 708
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:226 → 509
    Dynamin_M; Dynamin central region
    pfam02212
    Location:621 → 709
    GED; Dynamin GTPase effector domain

  2. XM_005163050.3 → XP_005163107.1  dynamin-1-like protein isoform X3

    UniProtKB/TrEMBL
    A0A8M2BA46
    Conserved Domains (4) summary
    cd08771
    Location:23 → 313
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:99 → 696
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:238 → 521
    Dynamin_M; Dynamin central region
    pfam02212
    Location:609 → 697
    GED; Dynamin GTPase effector domain

  3. XM_005163048.4 → XP_005163105.1  dynamin-1-like protein isoform X1

    UniProtKB/TrEMBL
    A0A8M2BAD6
    Conserved Domains (4) summary
    cd08771
    Location:23 → 313
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:99 → 720
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:238 → 521
    Dynamin_M; Dynamin central region
    pfam02212
    Location:633 → 721
    GED; Dynamin GTPase effector domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7SXN5.1 GenPept UniProtKB/Swiss-Prot:Q7SXN5

Gene LinkOut

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