idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: idh3aprovided by ZNC
Official Full Name: isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alphaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1007
See related: Ensembl:ENSDARG00000030278 AllianceGenome:ZFIN:ZDB-GENE-040426-1007
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:56380; zgc:85631
Summary: Predicted to enable isocitrate dehydrogenase (NAD+) activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; mesoderm; musculature system; optic tectum; and pronephric duct. Human ortholog(s) of this gene implicated in retinitis pigmentosa 90. Orthologous to human IDH3A (isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (25766101..25829109)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (25670950..25734031)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables isocitrate dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables isocitrate dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in isocitrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

Names: isocitrate dehydrogenase (NAD(+)) 3 alpha; isocitrate dehydrogenase 3 (NAD+) alpha

NP_957245.2

EC 1.1.1.41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200951.2 → NP_957245.2 isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

See identical proteins and their annotated locations for NP_957245.2

Status: PROVISIONAL

Source sequence(s)

BC068333

UniProtKB/TrEMBL

A0A8M1PG19, Q6NV33

Related

ENSDARP00000094415.4, ENSDART00000103638.6

Conserved Domains (1) summary

TIGR00175
Location:29 → 361

mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type