ppil2 peptidylprolyl isomerase (cyclophilin)-like 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ppil2provided by ZNC
Official Full Name: peptidylprolyl isomerase (cyclophilin)-like 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1096
See related: Ensembl:ENSDARG00000002016 AllianceGenome:ZFIN:ZDB-GENE-040426-1096
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:56616; zgc:86735; si:dkeyp-86g2.1
Summary: Predicted to enable peptidyl-prolyl cis-trans isomerase activity and ubiquitin-ubiquitin ligase activity. Predicted to be involved in protein peptidyl-prolyl isomerization and protein polyubiquitination. Predicted to act upstream of or within protein folding and protein ubiquitination. Predicted to be active in nucleus. Orthologous to human PPIL2 (peptidylprolyl isomerase like 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (12908781..12979975)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (12408564..12479758)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RING-type E3 ubiquitin-protein ligase PPIL2

Names: DKEYP-86G2.1

NP_957285.2

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200991.2 → NP_957285.2 RING-type E3 ubiquitin-protein ligase PPIL2

See identical proteins and their annotated locations for NP_957285.2

Status: PROVISIONAL

Source sequence(s)

BC071410

UniProtKB/TrEMBL

Q6IQJ6

Related

ENSDARP00000051662.5, ENSDART00000051663.7

Conserved Domains (2) summary

smart00504
Location:42 → 96

Ubox; Modified RING finger domain

cd01923
Location:281 → 440

cyclophilin_RING; cyclophilin_RING: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal ...