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pdk2b pyruvate dehydrogenase kinase 2b [ Danio rerio (zebrafish) ]

Gene ID: 393971, updated on 2-Nov-2024

Summary

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Official Symbol
pdk2bprovided by ZNC
Official Full Name
pyruvate dehydrogenase kinase 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-939
See related
Ensembl:ENSDARG00000059054 AllianceGenome:ZFIN:ZDB-GENE-040426-939
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Pdk; pdk2; zgc:56209
Summary
Predicted to enable pyruvate dehydrogenase (acetyl-transferring) kinase activity. Predicted to be involved in regulation of acetyl-CoA biosynthetic process from pyruvate and regulation of glucose metabolic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in cardiac ventricle. Orthologous to human PDK2 (pyruvate dehydrogenase kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See pdk2b in Genome Data Viewer
Location:
chromosome: 19
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (5674912..5687743)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (5756660..5769491)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene si:ch211-264f5.2 Neighboring gene alpha(1,3)fucosyltransferase gene 2 Neighboring gene alpha(1,3)fucosyltransferase gene 1 Neighboring gene zgc:174904 Neighboring gene si:ch211-264f5.6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. Sips PY, et al. PLoS One, 2018. PMID 29879736, Free PMC Article
  2. A novel test for recessive contributions to complex diseases implicates Bardet-Biedl syndrome gene BBS10 in idiopathic type 2 diabetes and obesity. Lim ET, et al. Am J Hum Genet, 2014 Nov 6. PMID 25439097, Free PMC Article
  3. The involvement of cholesterol in sepsis and tolerance to lipopolysaccharide highlighted by the transcriptome analysis of zebrafish (Danio rerio). Dios S, et al. Zebrafish, 2014 Oct. PMID 25181277, Free PMC Article
  4. HIF signaling and overall gene expression changes during hypoxia and prolonged exercise differ considerably. Kopp R, et al. Physiol Genomics, 2011 May 13. PMID 21343420
  5. Altered Glycolysis and Mitochondrial Respiration in a Zebrafish Model of Dravet Syndrome. Kumar MG, et al. eNeuro, 2016 Mar-Apr. PMID 27066534, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC56209

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pyruvate dehydrogenase kinase 2b
Names
pyruvate dehydrogenase kinase, isoenzyme 2
pyruvate dehydrogenase kinase, isoenzyme 2b
pyruvate dehydrogenase kinase, isozyme 2b
NP_957290.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200996.1 → NP_957290.1  pyruvate dehydrogenase kinase 2b

    See identical proteins and their annotated locations for NP_957290.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045993
    UniProtKB/TrEMBL
    Q7ZV57
    Related
    ENSDARP00000042188.6, ENSDART00000042189.7
    Conserved Domains (3) summary
    smart00387
    Location:242 → 362
    HATPase_c; Histidine kinase-like ATPases
    COG0642
    Location:196 → 370
    BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
    pfam10436
    Location:30 → 192
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    5674912..5687743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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