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nek2 NIMA-related kinase 2 [ Danio rerio (zebrafish) ]

Gene ID: 394025, updated on 2-Nov-2024

Summary

Official Symbol
nek2provided by ZNC
Official Full Name
NIMA-related kinase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-752
See related
Ensembl:ENSDARG00000005619 AllianceGenome:ZFIN:ZDB-GENE-040426-752
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55602
Summary
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within retinal rod cell development. Predicted to be active in centrosome; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa 67. Orthologous to human NEK2 (NIMA related kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See nek2 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (13883165..13893910)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (13987185..13997930)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene opsin 8, group member c Neighboring gene lysophosphatidylglycerol acyltransferase 1 Neighboring gene solute carrier family 30 member 1a Neighboring gene si:dkey-249p7.4

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Clone Names

  • MGC55602

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding  
enables kinase activity  
enables protein kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables transferase activity  
Component Evidence Code Pubs
is_active_in centrosome  
is_active_in cytoplasm  
is_active_in nucleus  

General protein information

Preferred Names
serine/threonine-protein kinase Nek2
Names
NIMA (never in mitosis gene a)-related kinase 2
NP_957344.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201050.1NP_957344.1  serine/threonine-protein kinase Nek2

    See identical proteins and their annotated locations for NP_957344.1

    Status: PROVISIONAL

    Source sequence(s)
    BC048055
    UniProtKB/TrEMBL
    A0A2R8Q6P9, F6P194, Q7ZUN2
    Related
    ENSDARP00000020452.5, ENSDART00000003248.8
    Conserved Domains (2) summary
    smart00220
    Location:8267
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08217
    Location:7271
    STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    13883165..13893910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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