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ephx1 epoxide hydrolase 1, microsomal (xenobiotic) [ Danio rerio (zebrafish) ]

Gene ID: 394043, updated on 2-Nov-2024

Summary

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Official Symbol
ephx1provided by ZNC
Official Full Name
epoxide hydrolase 1, microsomal (xenobiotic)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-913
See related
Ensembl:ENSDARG00000042854 AllianceGenome:ZFIN:ZDB-GENE-040426-913
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56126
Summary
Predicted to enable epoxide hydrolase activity. Predicted to be involved in epoxide metabolic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See ephx1 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (36628274..36638179)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (36725395..36735300)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene ENAH actin regulator Neighboring gene golgin subfamily A member 6-like protein 25 Neighboring gene signal recognition particle 9 Neighboring gene solute carrier family 5 member 6a Neighboring gene ribosomal protein L7-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Time-Related Alteration of Aqueous-Phase Anthracene and Phenanthrene Photoproducts in the Presence of TiO(2) Nanoparticles. St Mary L, et al. Environ Sci Technol, 2021 Mar 16. PMID 33651588, Free PMC Article
  2. Co-exposure to environmental carcinogens in vivo induces neoplasia-related hallmarks in low-genotoxicity events, even after removal of insult. Martins M, et al. Sci Rep, 2018 Feb 26. PMID 29483554, Free PMC Article
  3. Multibiomarker-based assessment of toxicity of central European strains of filamentous cyanobacteria Aphanizomenon gracile and Raphidiopsis raciborskii to zebrafish Danio rerio. Falfushynska H, et al. Water Res, 2021 Apr 15. PMID 33631698
  4. Comprehensive understanding of PM(2.5) on gene and microRNA expression patterns in zebrafish (Danio rerio) model. Duan J, et al. Sci Total Environ, 2017 May 15. PMID 28215799
  5. Activating transcription factor 3 coordinates differentiation of cardiac and hematopoietic progenitors by regulating glucose metabolism. Yin HM, et al. Sci Adv, 2020 May. PMID 32494702, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC56126

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables cis-stilbene-oxide hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables epoxide hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ether hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epoxide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
epoxide hydrolase 1
NP_957362.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201068.1 → NP_957362.1  epoxide hydrolase 1

    See identical proteins and their annotated locations for NP_957362.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045930
    UniProtKB/TrEMBL
    Q7ZVB4
    Related
    ENSDARP00000062897.3, ENSDART00000062898.6
    Conserved Domains (3) summary
    COG0596
    Location:114 → 450
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam06441
    Location:50 → 152
    EHN; Epoxide hydrolase N terminus
    cl21494
    Location:124 → 283
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    36628274..36638179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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