pex5 peroxisomal biogenesis factor 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pex5provided by ZNC
Official Full Name: peroxisomal biogenesis factor 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-981
See related: Ensembl:ENSDARG00000070654 AllianceGenome:ZFIN:ZDB-GENE-040426-981
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: PXR1; zgc:56318
Summary: Predicted to enable peroxisome matrix targeting signal-1 binding activity. Predicted to be involved in protein import into peroxisome matrix, docking. Predicted to be active in cytosol and peroxisomal membrane. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 2A; peroxisome biogenesis disorder 2B; and rhizomelic chondrodysplasia punctata type 5. Orthologous to human PEX5 (peroxisomal biogenesis factor 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (12064576..12097466, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (12173673..12206560, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PEX13 prevents pexophagy by regulating ubiquitinated PEX5 and peroxisomal ROS.
Title: PEX13 prevents pexophagy by regulating ubiquitinated PEX5 and peroxisomal ROS.
Loss of pex5 sensitizes zebrafish to fasting due to deregulated mitochondria, mTOR, and autophagy.
Title: Loss of pex5 sensitizes zebrafish to fasting due to deregulated mitochondria, mTOR, and autophagy.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables peroxisome matrix targeting signal-1 binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein import into peroxisome matrix, docking	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal matrix	IEA Inferred from Electronic Annotation more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: peroxisomal biogenesis factor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201156.1 → NP_957450.1 peroxisomal biogenesis factor 5

See identical proteins and their annotated locations for NP_957450.1

Status: PROVISIONAL

Source sequence(s)

BC046070

UniProtKB/TrEMBL

Q7ZUZ1

Related

ENSDARP00000094720.3, ENSDART00000103944.5

Conserved Domains (3) summary

sd00006
Location:436 → 464

TPR; TPR repeat [structural motif]

pfam00515
Location:473 → 503

TPR_1; Tetratricopeptide repeat

pfam13414
Location:435 → 501

TPR_11; TPR repeat

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

12064576..12097466 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009292089.3 → XP_009290364.1 peroxisomal biogenesis factor 5 isoform X1

UniProtKB/TrEMBL

A0A8M3AHU4

Conserved Domains (4) summary

sd00006
Location:481 → 509

TPR; TPR repeat [structural motif]

pfam00515
Location:518 → 548

TPR_1; Tetratricopeptide repeat

pfam13414
Location:480 → 546

TPR_11; TPR repeat

cl03428
Location:421 → 513

MAS20; MAS20 protein import receptor
XM_009292090.3 → XP_009290365.2 peroxisomal biogenesis factor 5 isoform X2

UniProtKB/TrEMBL

A0A8M3B1G9

Conserved Domains (2) summary

sd00006
Location:252 → 280

TPR; TPR repeat [structural motif]

cl26002
Location:101 → 348

TPR_11; TPR repeat