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oxsr1b oxidative stress responsive kinase 1b [ Danio rerio (zebrafish) ]

Gene ID: 394150, updated on 18-Sep-2024

Summary

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Official Symbol
oxsr1bprovided by ZNC
Official Full Name
oxidative stress responsive kinase 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-723
See related
Ensembl:ENSDARG00000027500 AllianceGenome:ZFIN:ZDB-GENE-040426-723
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55494; zgc:77321
Summary
Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to act upstream of or within intracellular signal transduction and protein phosphorylation. Orthologous to human OXSR1 (oxidative stress responsive kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See oxsr1b in Genome Data Viewer
Location:
chromosome: 24
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (20063682..20152962, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (19919261..20008549, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene LIM domain-containing protein Neighboring gene solute carrier family 22 member 13b Neighboring gene solute carrier family 22 member 13-like Neighboring gene uncharacterized LOC101883052 Neighboring gene uncharacterized LOC103909751 Neighboring gene antifreeze protein Maxi-like Neighboring gene MYD88 innate immune signal transduction adaptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. In vivo analysis of choroid plexus morphogenesis in zebrafish. García-Lecea M, et al. PLoS One, 2008 Sep 1. PMID 18769618, Free PMC Article
  2. Co-option of the PRDM14-CBFA2T complex from motor neurons to pluripotent cells during vertebrate evolution. Kawaguchi M, et al. Development, 2019 Jan 28. PMID 30630825
  3. Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes. Garcia-Reyero N, et al. Bull Environ Contam Toxicol, 2016 Jun. PMID 27086301, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC55494

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular hyperosmotic response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of T cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase OSR1b
Names
oxidative stress responsive 1b
NP_957469.2
XP_068073146.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201175.3 → NP_957469.2  serine/threonine-protein kinase OSR1b

    See identical proteins and their annotated locations for NP_957469.2

    Status: VALIDATED

    Source sequence(s)
    BX247944, CR381686, EH577479, EH584806, EH602240
    UniProtKB/TrEMBL
    A0A8N7XIZ8, B2GS65, F1Q921, Q6NWY2
    Related
    ENSDARP00000115525.2, ENSDART00000147004.4
    Conserved Domains (2) summary
    smart00220
    Location:17 → 291
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06610
    Location:15 → 291
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    20063682..20152962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068217045.1 → XP_068073146.1  serine/threonine-protein kinase OSR1b isoform X1

RNA

  1. XR_011008551.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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