dynlrb1 dynein, light chain, roadblock-type 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dynlrb1provided by ZNC
Official Full Name: dynein, light chain, roadblock-type 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-989
See related: Ensembl:ENSDARG00000021582 AllianceGenome:ZFIN:ZDB-GENE-040426-989
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: DNCL2A; zgc:56335
Summary: Enables dynein intermediate chain binding activity. Acts upstream of or within transforming growth factor beta receptor signaling pathway. Part of dynein complex. Is expressed in ovarian follicle. Orthologous to human DYNLRB1 (dynein light chain roadblock-type 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (26604265..26608636)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (26366649..26371020)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the dynein light chain zkm23 is required for TGFbeta signaling in cultured zebrafish ovarian follicle cells.
Title: Requirement of a dynein light chain in transforming growth factor β signaling in zebrafish ovarian follicle cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein intermediate chain binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule-based movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of dynein complex	IDA Inferred from Direct Assay more info	PubMed
part_of dynein complex	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dynein light chain roadblock-type 1

Names: km23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.