edem1 ER degradation enhancer, mannosidase alpha-like 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: edem1provided by ZNC
Official Full Name: ER degradation enhancer, mannosidase alpha-like 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-808
See related: Ensembl:ENSDARG00000025094 AllianceGenome:ZFIN:ZDB-GENE-040426-808
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55816
Summary: Predicted to enable calcium ion binding activity and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in endoplasmic reticulum unfolded protein response; mannoprotein catabolic process; and ubiquitin-dependent glycoprotein ERAD pathway. Predicted to act upstream of or within carbohydrate metabolic process; endoplasmic reticulum mannose trimming; and mannose trimming involved in glycoprotein ERAD pathway. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in anterior axial hypoblast; hatching gland; head; liver; and polster. Orthologous to human EDEM1 (ER degradation enhancing alpha-mannosidase like protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (42932757..42949182, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (42935221..42951646, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Naringenin also attenuated hepatic apoptosis in larvae as detected by TUNEL staining, consistent with the expression of critical biomarkers of endoplasmic reticulum stress and of DNA damage genes (chop, gadd45alphaa and edem1). The present study showed that naringenin inhibited alcohol-induced liver steatosis and injury in zebrafish larvae by reducing apoptosis and DNA damage and by harmonizing alcohol and lipid metabo...
Title: Naringenin inhibits alcoholic injury by improving lipid metabolism and reducing apoptosis in zebrafish larvae.

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General gene information

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Markers

fi87d05.x1 (e-PCR)
- UniSTS:198144

fd17h05.y1 (e-PCR)
- UniSTS:195233

fb66b10.y1 (e-PCR)
- UniSTS:190919

fk23c04.y1 (e-PCR)
- UniSTS:200667

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endoplasmic reticulum mannose trimming	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in mannoprotein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mannose trimming involved in glycoprotein ERAD pathway	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent glycoprotein ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ER degradation-enhancing alpha-mannosidase-like protein 1

NP_957483.2

EC 3.2.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201189.2 → NP_957483.2 ER degradation-enhancing alpha-mannosidase-like protein 1

Status: VALIDATED

Source sequence(s)

BX950172, EH488974

UniProtKB/TrEMBL

A0A8M1PFS6, E9QJF1

Related

ENSDARP00000120614.1, ENSDART00000147208.3

Conserved Domains (1) summary

pfam01532
Location:122 → 571

Glyco_hydro_47; Glycosyl hydrolase family 47