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qars1 glutaminyl-tRNA synthetase 1 [ Danio rerio (zebrafish) ]

Gene ID: 394188, updated on 17-Aug-2024

Summary

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Official Symbol
qars1provided by ZNC
Official Full Name
glutaminyl-tRNA synthetase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1011
See related
Ensembl:ENSDARG00000010316 AllianceGenome:ZFIN:ZDB-GENE-040426-1011
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
qars; zgc:56395
Summary
Predicted to enable glutamine-tRNA ligase activity. Predicted to be involved in glutaminyl-tRNA aminoacylation. Predicted to act upstream of or within tRNA aminoacylation for protein translation. Predicted to be located in cytoplasm. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Predicted to be active in cytosol. Is expressed in liver. Orthologous to human QARS1 (glutaminyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See qars1 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (46353336..46386060, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (46345457..46378181, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene mechanistic target of rapamycin kinase Neighboring gene angiopoietin-like 7 Neighboring gene si:dkey-75a21.2 Neighboring gene proline-rich transmembrane protein 3-like Neighboring gene 8-oxoguanine DNA glycosylase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Def functions as a cell autonomous factor in organogenesis of digestive organs in zebrafish. Tao T, et al. PLoS One, 2013. PMID 23593122, Free PMC Article
  2. A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases. Waldron AL, et al. PLoS One, 2017. PMID 28934368, Free PMC Article
  3. mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis. Scheldeman C, et al. Neurobiol Dis, 2017 Dec. PMID 28888969
  4. Biallelic variants in KARS1 are associated with neurodevelopmental disorders and hearing loss recapitulated by the knockout zebrafish. Lin SJ, et al. Genet Med, 2021 Oct. PMID 34172899, Free PMC Article
  5. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC56395

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutaminyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glutaminyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glutamine--tRNA ligase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001423662.1 → NP_001410591.1  glutamine--tRNA ligase

    Status: VALIDATED

    Source sequence(s)
    CR450703

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    46353336..46386060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_201213.1: Suppressed sequence

    Description
    NM_201213.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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