bmi1b bmi1 polycomb ring finger oncogene 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bmi1bprovided by ZNC
Official Full Name: bmi1 polycomb ring finger oncogene 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040116-4
See related: Ensembl:ENSDARG00000013076 AllianceGenome:ZFIN:ZDB-GENE-040116-4
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pcgf4b
Summary: Predicted to enable promoter-specific chromatin binding activity. Acts upstream of or within cerebellum development. Predicted to be located in nucleus. Predicted to be part of PRC1 complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; and hepatocellular carcinoma. Orthologous to several human genes including COMMD3-BMI1 (COMMD3-BMI1 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (21164930..21170517, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (21506872..21512207, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables promoter-specific chromatin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cerebellum development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression, epigenetic	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of PRC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PcG protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: polycomb complex protein BMI-1-B

Names: B lymphoma Mo-MLV insertion region 1b; polycomb group RING finger protein 4-B; polycomb group ring finger 4 B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080751.2 → NP_001074220.1 polycomb complex protein BMI-1-B

See identical proteins and their annotated locations for NP_001074220.1

Status: VALIDATED

Source sequence(s)

CR388093

UniProtKB/Swiss-Prot

Q7T3E6

Related

ENSDARP00000115422.1, ENSDART00000135417.3

Conserved Domains (2) summary

pfam00097
Location:18 → 56

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam16207
Location:146 → 224

RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

21164930..21170517 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021479461.2 → XP_021335136.1 polycomb complex protein BMI-1-B isoform X1

UniProtKB/TrEMBL

A0A8M9QHB6

Related

ENSDARP00000157311.1, ENSDART00000185792.1

Conserved Domains (3) summary

pfam16207
Location:162 → 226

RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

cd16736
Location:14 → 67

RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins

cl28410
Location:10 → 153

RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]