cdc6 cell division cycle 6 homolog (S. cerevisiae) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cdc6provided by ZNC
Official Full Name: cell division cycle 6 homolog (S. cerevisiae)provided by ZNC
Primary source: ZFIN:ZDB-GENE-050506-131
See related: Ensembl:ENSDARG00000009942 AllianceGenome:ZFIN:ZDB-GENE-050506-131
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7145727; zgc:174506
Summary: Predicted to enable DNA replication origin binding activity. Acts upstream of or within mitotic cell cycle phase transition. Predicted to be active in nucleus. Is expressed in central nervous system and proliferative region. Used to study Meier-Gorlin syndrome. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Orthologous to human CDC6 (cell division cycle 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (11783470..11792696, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (11799849..11809075, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In zebrafish cdc6tsu4305 mutant embryos partially represses cell death phenotype, suggesting that the human CDC6(T323R) mutation is a hypomorph.
Title: Zebrafish cdc6 hypomorphic mutation causes Meier-Gorlin syndrome-like phenotype.

Submit: New GeneRIF Correction

General gene information

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Markers

fe02h06.y1 (e-PCR)
- UniSTS:195956

fd19b06.x1 (e-PCR)
- UniSTS:195240

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA replication origin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA replication initiation	IEA Inferred from Electronic Annotation more info
involved_in DNA replication initiation	IEA Inferred from Electronic Annotation more info
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic DNA replication checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic cell cycle phase transition	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cell division control protein 6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127333.1 → NP_001120805.1 cell division control protein 6 homolog

See identical proteins and their annotated locations for NP_001120805.1

Status: PROVISIONAL

Source sequence(s)

BC154325

UniProtKB/TrEMBL

A8KC19

Related

ENSDARP00000008736.6, ENSDART00000011657.7

Conserved Domains (3) summary

smart01074
Location:474 → 546

Cdc6_C; CDC6, C terminal

COG1474
Location:184 → 548

CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]

pfam13191
Location:187 → 323

AAA_16; AAA ATPase domain