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e2f5 E2F transcription factor 5 [ Danio rerio (zebrafish) ]

Gene ID: 402908, updated on 2-Nov-2024

Summary

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Official Symbol
e2f5provided by ZNC
Official Full Name
E2F transcription factor 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-030828-3
See related
Ensembl:ENSDARG00000038812 AllianceGenome:ZFIN:ZDB-GENE-030828-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
E2F4; cb735; zgc:111879
Summary
Enables DNA-binding transcription factor activity. Acts upstream of or within female somatic sex determination; male meiosis I; and multi-ciliated epithelial cell differentiation. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including Kupffer's vesicle; forerunner cell group; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human E2F5 (E2F transcription factor 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See e2f5 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (31676788..31686408, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (31693570..31703351, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene si:ch211-106h4.12 Neighboring gene atypical chemokine receptor 4a Neighboring gene leucine rich repeat and coiled-coil centrosomal protein 1 Neighboring gene RALY RNA binding protein like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification and expression analysis of two zebrafish E2F5 genes during oogenesis and development. Yang Q, et al. Mol Biol Rep, 2010 Apr. PMID 19578977
  2. E2F4/5-mediated transcriptional control of multiciliated cell differentiation: redundancy or fine-tuning? Stracker TH. Dev Biol, 2019 Feb 1. PMID 30537487
  3. Identification of adverse outcome pathway related to high-density polyethylene microplastics exposure: Caenorhabditis elegans transcription factor RNAi screening and zebrafish study. Kim Y, et al. J Hazard Mater, 2020 Apr 15. PMID 31806443
  4. Distinct requirements of E2f4 versus E2f5 activity for multiciliated cell development in the zebrafish embryo. Chong YL, et al. Dev Biol, 2018 Nov 15. PMID 30218642
  5. Conservation as well as divergence in Mcidas function underlies the differentiation of multiciliated cells in vertebrates. Zhou F, et al. Dev Biol, 2020 Sep 15. PMID 32735790

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that E2f5 can function as a versatile transcriptional activator and identify novel roles of the protein in spermatogenesis as well as MCC differentiation during zebrafish development.
    Title: E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish.
  2. Transcription factors E2f4 iand E2f5 are required for multiciliogenesis in zebrafish.
    Title: E2F4/5-mediated transcriptional control of multiciliated cell differentiation: redundancy or fine-tuning?
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC111879

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within female somatic sex determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within male meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multi-ciliated epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription factor E2F5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197300.1 → NP_001184229.1  transcription factor E2F5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    CK017425, CR293515, EB911484
    UniProtKB/TrEMBL
    A0A8M1NXA0, A5WUE8
    Related
    ENSDARP00000056678.6, ENSDART00000056679.8
    Conserved Domains (3) summary
    COG5665
    Location:74 → 328
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    cd14660
    Location:97 → 201
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:21 → 85
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

  2. NM_205615.2 → NP_991178.1  transcription factor E2F5 isoform 2

    See identical proteins and their annotated locations for NP_991178.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant differs in the 3' CDS and 3' UTR compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    CR293515
    UniProtKB/TrEMBL
    A0A8M1PGG3, Q6TH18
    Related
    ENSDARP00000111176.2, ENSDART00000126177.3
    Conserved Domains (3) summary
    cd14660
    Location:97 → 132
    E2F_DD; coiled coil [structural motif]
    pfam02319
    Location:21 → 85
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    cl22411
    Location:97 → 141
    E2F_DD; Dimerization domain of E2F transcription factors

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    31676788..31686408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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