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bcor BCL6 corepressor [ Danio rerio (zebrafish) ]

Gene ID: 402921, updated on 27-Mar-2024

Summary

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Official Symbol
bcorprovided by ZNC
Official Full Name
BCL6 corepressorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040408-1
See related
Ensembl:ENSDARG00000017798 AllianceGenome:ZFIN:ZDB-GENE-040408-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable transcription corepressor activity. Acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; neural tube development; and retina morphogenesis in camera-type eye. Human ortholog(s) of this gene implicated in colorectal cancer; stomach cancer; stomach carcinoma; syndromic microphthalmia 1; and syndromic microphthalmia 2. Orthologous to human BCOR (BCL6 corepressor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See bcor in Genome Data Viewer
Location:
chromosome: 22
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (11144153..11200807)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (11114261..11170556)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101882843 Neighboring gene ATPase H+ transporting accessory protein 2 Neighboring gene uncharacterized LOC103909557 Neighboring gene MID1 interacting protein 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Long-range evolutionary constraints reveal cis-regulatory interactions on the human X chromosome. Naville M, et al. Nat Commun, 2015 Apr 24. PMID 25908307, Free PMC Article
  2. Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR. Ng D, et al. Nat Genet, 2004 Apr. PMID 15004558
  3. Heritable transmission of diabetic metabolic memory in zebrafish correlates with DNA hypomethylation and aberrant gene expression. Olsen AS, et al. Diabetes, 2012 Feb. PMID 22228713, Free PMC Article
  4. Bcl6a function is required during optic cup formation to prevent p53-dependent apoptosis and colobomata. Lee J, et al. Hum Mol Genet, 2013 Sep 1. PMID 23669349, Free PMC Article
  5. Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish. Zhang C, et al. Fish Shellfish Immunol, 2019 Nov. PMID 31546038

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neural tube development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within retina morphogenesis in camera-type eye IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within retina morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
BCL-6 corepressor
Names
BCL6 co-repressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205626.1 → NP_991189.1  BCL-6 corepressor

    See identical proteins and their annotated locations for NP_991189.1

    Status: PROVISIONAL

    Source sequence(s)
    AY316593
    UniProtKB/TrEMBL
    A0A8M1PGH9, Q6W2J8
    Related
    ENSDARP00000047441.7, ENSDART00000047442.9
    Conserved Domains (5) summary
    cd00204
    Location:1480 → 1587
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14261
    Location:1651 → 1767
    PUFD; PCGF Ub-like fold discriminator of BCOR
    pfam12796
    Location:1490 → 1581
    Ank_2; Ankyrin repeats (3 copies)
    pfam15808
    Location:1195 → 1429
    BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
    sd00045
    Location:1486 → 1517
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    11144153..11200807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173943.4 → XP_005174000.1  BCL-6 corepressor isoform X1

    UniProtKB/TrEMBL
    A0A8M2BLL2, F1RCL8
    Related
    ENSDARP00000092882.4, ENSDART00000102106.5
    Conserved Domains (5) summary
    cd00204
    Location:1499 → 1606
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14261
    Location:1670 → 1786
    PUFD; PCGF Ub-like fold discriminator of BCOR
    pfam12796
    Location:1509 → 1600
    Ank_2; Ankyrin repeats (3 copies)
    pfam15808
    Location:1214 → 1448
    BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
    sd00045
    Location:1505 → 1536
    ANK; ANK repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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