pitx3 paired-like homeodomain 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pitx3provided by ZNC
Official Full Name: paired-like homeodomain 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-041229-4
See related: Ensembl:ENSDARG00000070069 AllianceGenome:ZFIN:ZDB-GENE-041229-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:109716
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within adenohypophysis development; lens fiber cell differentiation; and positive regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including ectoderm; head; immature eye; nervous system; and neurogenic field. Human ortholog(s) of this gene implicated in anterior segment dysgenesis; anterior segment dysgenesis 1; cataract; cataract 11 multiple types; and cataract 9 multiple types. Orthologous to human PITX3 (paired like homeodomain 3). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (7556315..7573670, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (7224113..7241468, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

while lmx1b paralogues may contribute to the generation of diencephalic dopaminergic precursors. Conversely, knock-down of pitx3 does not specifically affect any diencephalic dopamine cluster
Title: Expression and function of nr4a2, lmx1b, and pitx3 in zebrafish dopaminergic and noradrenergic neuronal development.
results demonstrate zebrafish pitx3 represents a true ortholog of the human PITX3 gene and the general function of the Pitx3 protein in lens development is conserved between mammals and the teleost fish
Title: Zebrafish pitx3 is necessary for normal lens and retinal development.
Data demonstrate that Foxe3 is necessary for lens development in zebrafish and that foxe3 lies genetically downstream of pitx3 in a zebrafish lens development pathway.
Title: Zebrafish foxe3: roles in ocular lens morphogenesis through interaction with pitx3.
expressing cells constitute an equivalence domain of cells that can form either pituitary or lens
Title: pitx3 defines an equivalence domain for lens and anterior pituitary placode.
pitx3 expression in the primordia of the pituitary, lens, olfactory mucosa, and cranial ganglia is modulated by hedgehog and nodal proteins' signaling.
Title: Modulation of zebrafish pitx3 expression in the primordia of the pituitary, lens, olfactory epithelium and cranial ganglia by hedgehog and nodal signaling.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adenohypophysis development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocrine system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens fiber cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pituitary homeobox 3

Names: bicoid-like homeodomain transcription factor 3; homeobox protein PITX3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205675.2 → NP_991238.1 pituitary homeobox 3

See identical proteins and their annotated locations for NP_991238.1

Status: PROVISIONAL

Source sequence(s)

AY525643

UniProtKB/Swiss-Prot

Q6DUF5, Q6QU75

UniProtKB/TrEMBL

B2GRZ8

Related

ENSDARP00000093314.4, ENSDART00000102538.6

Conserved Domains (3) summary

pfam00046
Location:64 → 116

Homeobox; Homeobox domain

pfam03826
Location:251 → 268

OAR; OAR domain

cl19886
Location:18 → 79

Cnd2; Condensin complex subunit 2