gja2 gap junction protein, alpha 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gja2provided by ZNC
Official Full Name: gap junction protein, alpha 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040406-2
See related: Ensembl:ENSDARG00000004082 AllianceGenome:ZFIN:ZDB-GENE-040406-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cx46l; cx39.9; zgc:110668
Summary: Predicted to enable gap junction channel activity. Acts upstream of or within cell communication by electrical coupling and slow-twitch skeletal muscle fiber contraction. Predicted to be located in gap junction and plasma membrane. Predicted to be part of connexin complex. Is expressed in several structures, including eye; kidney; liver; musculature system; and spinal cord. [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (23630416..23636389)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (23130884..23131945)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Connexin 39.9 facilitates the spreading of neuronal inputs, which is irregular during motor development, beyond the muscle cells and that gap junctions play an essential role in the efficient recruitment of slow muscle fibers.
Title: Connexin 39.9 protein is necessary for coordinated activation of slow-twitch muscle and normal behavior in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables gap junction channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell communication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell communication by electrical coupling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within slow-twitch skeletal muscle fiber contraction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
part_of connexin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of connexin complex	IEA Inferred from Electronic Annotation more info
located_in gap junction	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: gap junction protein, alpha 2

Names: connexin 39.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212826.1 → NP_997991.1 gap junction protein, alpha 2

See identical proteins and their annotated locations for NP_997991.1

Status: PROVISIONAL

Source sequence(s)

AY135445

UniProtKB/TrEMBL

Q8AWR4

Related

ENSDARP00000107852.2, ENSDART00000125161.3

Conserved Domains (3) summary

smart00037
Location:44 → 76

CNX; Connexin homologues

smart01089
Location:155 → 221

Connexin_CCC; Gap junction channel protein cysteine-rich domain

pfam00029
Location:3 → 223

Connexin; Connexin

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

23630416..23636389

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021476053.2 → XP_021331728.1 gap junction protein, alpha 2 isoform X1

UniProtKB/TrEMBL

B0R0X0, F1R2M4

Related

ENSDARP00000111351.2, ENSDART00000013745.6

Conserved Domains (1) summary

pfam00029
Location:3 → 223

Connexin; Connexin