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Fkbpl FKBP prolyl isomerase like [ Rattus norvegicus (Norway rat) ]

Gene ID: 406168, updated on 2-Nov-2024

Summary

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Official Symbol
Fkbplprovided by RGD
Official Full Name
FKBP prolyl isomerase likeprovided by RGD
Primary source
RGD:1303227
See related
EnsemblRapid:ENSRNOG00000000432 AllianceGenome:RGD:1303227
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to act upstream of or within regulation of blood vessel branching. Predicted to be located in extracellular region. Orthologous to human FKBPL (FKBP prolyl isomerase like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 198.9), Muscle (RPKM 72.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fkbpl in Genome Data Viewer
Location:
20p12
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4104457..4105927, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4099845..4101315, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4411890..4413360)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483856 Neighboring gene uncharacterized LOC120098978 Neighboring gene activating transcription factor 6 beta Neighboring gene palmitoyl-protein thioesterase 2 Neighboring gene proline-rich transmembrane protein 1 Neighboring gene EGF-like-domain, multiple 8 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FKBPL is a critical antiangiogenic regulator of developmental and pathological angiogenesis. Yakkundi A, et al. Arterioscler Thromb Vasc Biol, 2015 Apr. PMID 25767277, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of blood vessel branching ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
FK506-binding protein-like
Names
FK506 binding protein-like
WAF-1/CIP1 stabilizing protein 39
WISp39
NP_001002818.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002818.2 → NP_001002818.1  FK506-binding protein-like

    See identical proteins and their annotated locations for NP_001002818.1

    Status: VALIDATED

    Source sequence(s)
    BC086532
    UniProtKB/Swiss-Prot
    Q6MG81
    UniProtKB/TrEMBL
    A6KTJ1
    Related
    ENSRNOP00000000494.3, ENSRNOT00000000494.8
    Conserved Domains (3) summary
    sd00006
    Location:208 → 236
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:285 → 317
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:252 → 315
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    4104457..4105927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6MG81.1 GenPept UniProtKB/Swiss-Prot:Q6MG81

Gene LinkOut

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