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hnrnpk heterogeneous nuclear ribonucleoprotein K [ Danio rerio (zebrafish) ]

Gene ID: 406267, updated on 2-Nov-2024

Summary

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Official Symbol
hnrnpkprovided by ZNC
Official Full Name
heterogeneous nuclear ribonucleoprotein Kprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1926
See related
Ensembl:ENSDARG00000018914 AllianceGenome:ZFIN:ZDB-GENE-040426-1926
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hnrpk; zgc:66162; wu:fb37h02; wu:fi34c04
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in regulation of mRNA splicing, via spliceosome and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; gut; otic vesicle; pectoral fin; and ventral mesoderm. Human ortholog(s) of this gene implicated in Raynaud disease. Orthologous to human HNRNPK (heterogeneous nuclear ribonucleoprotein K). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See hnrnpk in Genome Data Viewer
Location:
chromosome: 8
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (49745668..49766241, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (49756899..49777472, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene G kinase anchoring protein 1 Neighboring gene Q-nucleotide N-glycosylase 1 Neighboring gene RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) Neighboring gene neurotrophic tyrosine kinase, receptor, type 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A Genetic Model to Study Increased Hexosamine Biosynthetic Flux. Hugo SE, et al. Endocrinology, 2017 Aug 1. PMID 28582574, Free PMC Article
  2. Identification of nodal signaling targets by array analysis of induced complex probes. Dickmeis T, et al. Dev Dyn, 2001 Dec. PMID 11748827
  3. Evolution after Whole-Genome Duplication: Teleost MicroRNAs. Desvignes T, et al. Mol Biol Evol, 2021 Jul 29. PMID 33871629, Free PMC Article
  4. Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio). Boswell M, et al. Sci Rep, 2020 Feb 24. PMID 32094353, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein K

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212994.2 → NP_998159.2  heterogeneous nuclear ribonucleoprotein K

    See identical proteins and their annotated locations for NP_998159.2

    Status: VALIDATED

    Source sequence(s)
    BI704444, CR376792, CU682767, DR719329, EB912144
    UniProtKB/TrEMBL
    A0A8M3B580, F1QWB4
    Related
    ENSDARP00000088691.3, ENSDART00000097919.5
    Conserved Domains (3) summary
    cd00105
    Location:355 → 418
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:122 → 183
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam08067
    Location:9 → 43
    ROKNT; ROKNT (NUC014) domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    49745668..49766241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167319.5 → XP_005167376.1  heterogeneous nuclear ribonucleoprotein K isoform X3

    UniProtKB/TrEMBL
    A0A2R8Q139, A0A8M2BEM9
    Related
    ENSDARP00000146195.1, ENSDART00000189142.1
    Conserved Domains (3) summary
    cd00105
    Location:343 → 406
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:122 → 183
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam08067
    Location:9 → 43
    ROKNT; ROKNT (NUC014) domain

  2. XM_068222911.1 → XP_068079012.1  heterogeneous nuclear ribonucleoprotein K isoform X2

  3. XM_009304280.4 → XP_009302555.1  heterogeneous nuclear ribonucleoprotein K isoform X1

    See identical proteins and their annotated locations for XP_009302555.1

    UniProtKB/TrEMBL
    A0A8M3B580, F1QWB4
    Conserved Domains (3) summary
    cd00105
    Location:355 → 418
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:122 → 183
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam08067
    Location:9 → 43
    ROKNT; ROKNT (NUC014) domain
Nucleotide Protein
Heading Accession and Version

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