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clta clathrin, light chain A [ Danio rerio (zebrafish) ]

Gene ID: 406318, updated on 2-Nov-2024

Summary

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Official Symbol
cltaprovided by ZNC
Official Full Name
clathrin, light chain Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1986
See related
Ensembl:ENSDARG00000045618 AllianceGenome:ZFIN:ZDB-GENE-040426-1986
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:73358; wu:fb61d08; wu:fj48d06
Summary
Predicted to enable clathrin heavy chain binding activity. Predicted to be involved in clathrin-dependent endocytosis. Predicted to act upstream of or within intracellular protein transport and vesicle-mediated transport. Predicted to be located in clathrin-coated pit and cytoplasmic vesicle. Predicted to be part of clathrin vesicle coat. Predicted to be active in plasma membrane; postsynaptic endocytic zone cytoplasmic component; and synaptic vesicle membrane. Orthologous to human CLTA (clathrin light chain A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See clta in Genome Data Viewer
Location:
chromosome: 1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (12348242..12361930)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (11661417..11675130)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Neighboring gene N-acetylneuraminic acid synthase a Neighboring gene sodium channel and clathrin linker 1 Neighboring gene zgc:77739

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Novel transgenic lines to fluorescently label clathrin and caveolin endosomes in live zebrafish. Arbizzani F, et al. Zebrafish, 2015 Apr. PMID 25748563
  2. Synaptic vesicles are "primed" for fast clathrin-mediated endocytosis at the ribbon synapse. Pelassa I, et al. Front Mol Neurosci, 2014. PMID 25520613, Free PMC Article
  3. Rmrp Mutation Disrupts Chondrogenesis and Bone Ossification in Zebrafish Model of Cartilage-Hair Hypoplasia via Enhanced Wnt/β-Catenin Signaling. Sun X, et al. J Bone Miner Res, 2019 Nov. PMID 31237961
  4. Zebrafish miR-1 and miR-133 shape muscle gene expression and regulate sarcomeric actin organization. Mishima Y, et al. Genes Dev, 2009 Mar 1. PMID 19240126, Free PMC Article
  5. Gene Characterization of Nocturnin Paralogues in Goldfish: Full Coding Sequences, Structure, Phylogeny and Tissue Expression. Madera D, et al. Int J Mol Sci, 2023 Dec 19. PMID 38203224, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The development of transgenic zebrafish lines expressing CLTA fused to dsRed and CAV1 fused to GFP is reported.
    Title: Novel transgenic lines to fluorescently label clathrin and caveolin endosomes in live zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables clathrin heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of clathrin coat of coated pit IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin coat of trans-Golgi network vesicle IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic endocytic zone cytoplasmic component IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
clathrin light chain A
Names
clathrin, light chain (Lca)
clathrin, light polypeptide (Lca)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213045.1 → NP_998210.1  clathrin light chain A

    See identical proteins and their annotated locations for NP_998210.1

    Status: PROVISIONAL

    Source sequence(s)
    BC060939
    UniProtKB/TrEMBL
    A0A8M1PIK9, Q6P937
    Related
    ENSDARP00000067081.4, ENSDART00000067082.5
    Conserved Domains (1) summary
    pfam01086
    Location:1 → 234
    Clathrin_lg_ch; Clathrin light chain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    12348242..12361930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159805.4 → XP_005159862.1  clathrin light chain A isoform X1

    UniProtKB/TrEMBL
    A0A8M2B6P8, E9QDE6
    Related
    ENSDARP00000114058.1, ENSDART00000138759.3
    Conserved Domains (1) summary
    pfam01086
    Location:1 → 222
    Clathrin_lg_ch; Clathrin light chain

  2. XM_005159806.4 → XP_005159863.1  clathrin light chain A isoform X2

    UniProtKB/TrEMBL
    A0A8M2B6L7, E7F1Q8, E9QI07
    Related
    ENSDARP00000113917.1, ENSDART00000144920.3
    Conserved Domains (1) summary
    pfam01086
    Location:1 → 204
    Clathrin_lg_ch; Clathrin light chain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394464.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    5956..19627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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