uchl5 ubiquitin carboxyl-terminal hydrolase L5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: uchl5provided by ZNC
Official Full Name: ubiquitin carboxyl-terminal hydrolase L5provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2051
See related: Ensembl:ENSDARG00000103404 AllianceGenome:ZFIN:ZDB-GENE-040426-2051
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:85615; wu:fj17f09
Summary: Predicted to enable thiol-dependent deubiquitinase. Acts upstream of or within cranial skeletal system development. Predicted to be part of Ino80 complex. Predicted to be active in cytoplasm. Orthologous to human UCHL5 (ubiquitin C-terminal hydrolase L5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (24220937..24233856)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (24194373..24207292)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables proteasome binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cranial skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein deubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Ino80 complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase isozyme L5

NP_998249.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213084.1 → NP_998249.1 ubiquitin carboxyl-terminal hydrolase isozyme L5

See identical proteins and their annotated locations for NP_998249.1

Status: PROVISIONAL

Source sequence(s)

BC067545

UniProtKB/TrEMBL

A0A8N1TST1, Q6NWL6

Related

ENSDARP00000141540.1, ENSDART00000165380.2

Conserved Domains (1) summary

cd02255
Location:8 → 223

Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1