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cmpk cytidylate kinase [ Danio rerio (zebrafish) ]

Gene ID: 406383, updated on 2-Nov-2024

Summary

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Official Symbol
cmpkprovided by ZNC
Official Full Name
cytidylate kinaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2113
See related
Ensembl:ENSDARG00000019924 AllianceGenome:ZFIN:ZDB-GENE-040426-2113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
CK; ump; cmpk1; fb52d08; fk47a07; UMP/CMPK; zgc:56452; wu:fb52d08; wu:fk47a07
Summary
Predicted to enable (d)CMP kinase activity; UMP kinase activity; and nucleoside diphosphate kinase activity. Predicted to be involved in CDP biosynthetic process and UDP biosynthetic process. Predicted to act upstream of or within 'de novo' pyrimidine nucleobase biosynthetic process and phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in neural plate and notochord. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CMPK1 (cytidine/uridine monophosphate kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See cmpk in Genome Data Viewer
Location:
chromosome: 2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (10063765..10076943)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (10265945..10279123)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member A3b Neighboring gene family with sequence similarity 78 member Ba Neighboring gene BCL6A transcription repressor b Neighboring gene insulin-like 5b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables (d)CMP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables (d)CMP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables CMP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables UMP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UMP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables UMP/dUMP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables dCMP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleobase-containing compound kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in CDP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UDP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UMP-CMP kinase
Names
CMP kinase
cytidine monophosphate kinase
uridine monophosphate kinase
NP_998274.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213109.2 → NP_998274.2  UMP-CMP kinase

    Status: VALIDATED

    Source sequence(s)
    EH461618, EH472282, EH555529
    UniProtKB/Swiss-Prot
    Q7ZWE9
    UniProtKB/TrEMBL
    A0A8N1TQ43, A5WWI2
    Related
    ENSDARP00000008412.4, ENSDART00000014088.6
    Conserved Domains (2) summary
    cd01428
    Location:28 → 207
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01359
    Location:28 → 215
    UMP_CMP_kin_fam; UMP-CMP kinase family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    10063765..10076943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZWE9.2 GenPept UniProtKB/Swiss-Prot:Q7ZWE9

Gene LinkOut

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