gmfb glia maturation factor, beta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gmfbprovided by ZNC
Official Full Name: glia maturation factor, betaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2114
See related: Ensembl:ENSDARG00000028327 AllianceGenome:ZFIN:ZDB-GENE-040426-2114
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc25b01; zgc:56451; zgc:86831; wu:fa97c03; wu:fc25b01
Summary: Predicted to enable Arp2/3 complex binding activity. Acts upstream of or within reactive gliosis. Is expressed in head; hindbrain; and telencephalon. Orthologous to several human genes including GMFB (glia maturation factor beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (36585547..36593618)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (36459715..36467786)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glia maturation factor-beta is required for normal development of glial fibrillary acidic protein fibers in the telencephalon.
Title: Glia maturation factor beta is required for reactive gliosis after traumatic brain injury in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fa97c03.x1 (e-PCR)
- UniSTS:202617

fc25b01.x1 (e-PCR)
- UniSTS:193235

fc25b01.x1 (e-PCR)
- UniSTS:193236

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Arp2/3 complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables Arp2/3 complex binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament debranching	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin filament debranching	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within reactive gliosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to wounding	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glia maturation factor beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213110.1 → NP_998275.1 glia maturation factor beta

See identical proteins and their annotated locations for NP_998275.1

Status: PROVISIONAL

Source sequence(s)

BC049318

UniProtKB/TrEMBL

Q6DI15, Q7ZUD3

Related

ENSDARP00000038400.7, ENSDART00000030211.9

Conserved Domains (1) summary

cd11283
Location:9 → 130

ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins