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sqstm1 sequestosome 1 [ Danio rerio (zebrafish) ]

Gene ID: 406452, updated on 14-Apr-2024

Summary

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Official Symbol
sqstm1provided by ZNC
Official Full Name
sequestosome 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2204
See related
Ensembl:ENSDARG00000075014 AllianceGenome:ZFIN:ZDB-GENE-040426-2204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
p62; sb:cb621; zgc:85784
Summary
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and protein kinase C binding activity. Acts upstream of or within several processes, including axonogenesis; defense response to bacterium; and regulation of autophagy. Predicted to be located in lysosome. Predicted to be active in aggresome and amphisome. Is expressed in several structures, including digestive system; epidermis; mesoderm; nervous system; and tail bud. Human ortholog(s) of this gene implicated in GNE myopathy; Paget's disease of bone; and frontotemporal dementia and/or amyotrophic lateral sclerosis-3. Orthologous to human SQSTM1 (sequestosome 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See sqstm1 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (16765992..16771405)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (16460339..16465752)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene calnexin Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B Neighboring gene T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b Neighboring gene MRN complex interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Biallelic SQSTM1 mutations in early-onset, variably progressive neurodegeneration. Muto V, et al. Neurology, 2018 Jul 24. PMID 29959261, Free PMC Article
  2. A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism. Swinnen B, et al. Acta Neuropathol, 2018 Mar. PMID 29302778
  3. Rescue of Pink1 Deficiency by Stress-Dependent Activation of Autophagy. Zhang Y, et al. Cell Chem Biol, 2017 Apr 20. PMID 28366621
  4. Sqstm1 knock-down causes a locomotor phenotype ameliorated by rapamycin in a zebrafish model of ALS/FTLD. Lattante S, et al. Hum Mol Genet, 2015 Mar 15. PMID 25410659
  5. Autophagy participates in innate immune defense in lamprey. Luo L, et al. Fish Shellfish Immunol, 2018 Dec. PMID 30195918

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase C binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aggrephagy IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of autophagy IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in aggresome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in amphisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sequestosome-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001312913.1 → NP_001299842.1  sequestosome-1

    Status: VALIDATED

    Source sequence(s)
    CU075768, DR724012, EH505876, EH510853
    UniProtKB/TrEMBL
    A0A096X7A4, F1Q5Z8
    Related
    ENSDARP00000117113.1, ENSDART00000140061.3
    Conserved Domains (3) summary
    cd06402
    Location:3 → 88
    PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
    cd02340
    Location:148 → 190
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cl21463
    Location:390 → 448
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    16765992..16771405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_213173.1: Suppressed sequence

    Description
    NM_213173.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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