nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nfkbiaaprovided by ZNC
Official Full Name: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2227
See related: Ensembl:ENSDARG00000005481 AllianceGenome:ZFIN:ZDB-GENE-040426-2227
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ikbaA; fj16a07; zgc:85769; wu:fj16a07
Summary: Predicted to enable NF-kappaB binding activity and protein sequestering activity. Acts upstream of or within negative regulation of hematopoietic progenitor cell differentiation and response to virus. Predicted to be active in cytosol. Is expressed in several structures, including lateral line system; periderm; pronephric duct; tail bud; and vent. Human ortholog(s) of this gene implicated in several diseases, including childhood-onset asthma; ectodermal dysplasia and immunodeficiency 2; hematologic cancer (multiple); hepatitis B; and lung disease (multiple). Orthologous to human NFKBIA (NFKB inhibitor alpha). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (16881889..16884737)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (16982306..16985154)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Histone Deacetylases Cooperate with NF-kappaB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury.
Title: Histone Deacetylases Cooperate with NF-κB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury.
Zc3h8 represses NF-kappaB-mediated inflammation in digestive organs in zebrafish.
Title: The CCCH-type zinc finger transcription factor Zc3h8 represses NF-κB-mediated inflammation in digestive organs in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables NF-kappaB binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein sequestering activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of hematopoietic progenitor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to virus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a

Names: NF-kappaB inhibitor alpha-like protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213184.2 → NP_998349.2 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a

Status: VALIDATED

Source sequence(s)

CU855900, EH437254, EH466098

UniProtKB/TrEMBL

A0A8N1Z434, F1QCG4

Related

ENSDARP00000109941.2, ENSDART00000130107.4

Conserved Domains (5) summary

cd00204
Location:108 → 239

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:118 → 214

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:78 → 134

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:204 → 258

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:115 → 144

ANK; ANK repeat [structural motif]